Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The use of nanoparticles for pulmonary delivery poses challenges such as the presence of anatomical barriers and the loss of bioactive components. Excipients are often used to facilitate delivery. Excipients suitable for nanoparticle delivery are still being explored. Herein we introduce for the first time, spray-dried glycine microparticle-based excipients loaded with nanoparticles of the size range known to be taken up by alveolar macrophages. Using a microfluidic jet spray dryer, we produced glycine microparticles-based excipients which are spherical, uniform, cenospheric (hollow at core), and “coral-like” with average diameter of 60 ± 10 μm, 29 ± 0.8% porosity, and showed their effective loading with glycine coated iron oxide superparamagnetic nanoparticles (GSPIONs). Our loading protocol with nanoparticles further increased microsphere porosity and improved aerodynamic performance unlike the dense, solid commercial excipient, Lactohale200™. This demonstrates a feasible approach for delivery of such nanoparticles in the lung.

Original languageEnglish
Article number118654
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume570
DOIs
Publication statusPublished - 30 Oct 2019

Keywords

  • Glycine microparticle-based excipient
  • Inhalation
  • Iron oxide nanoparticles
  • Spray drying

Cite this

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title = "Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery",
abstract = "The use of nanoparticles for pulmonary delivery poses challenges such as the presence of anatomical barriers and the loss of bioactive components. Excipients are often used to facilitate delivery. Excipients suitable for nanoparticle delivery are still being explored. Herein we introduce for the first time, spray-dried glycine microparticle-based excipients loaded with nanoparticles of the size range known to be taken up by alveolar macrophages. Using a microfluidic jet spray dryer, we produced glycine microparticles-based excipients which are spherical, uniform, cenospheric (hollow at core), and “coral-like” with average diameter of 60 ± 10 μm, 29 ± 0.8{\%} porosity, and showed their effective loading with glycine coated iron oxide superparamagnetic nanoparticles (GSPIONs). Our loading protocol with nanoparticles further increased microsphere porosity and improved aerodynamic performance unlike the dense, solid commercial excipient, Lactohale200™. This demonstrates a feasible approach for delivery of such nanoparticles in the lung.",
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author = "Amlan Chakraborty and Royce, {Simon G.} and Magdalena Plebanski and Cordelia Selomulya",
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Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery. / Chakraborty, Amlan; Royce, Simon G.; Plebanski, Magdalena; Selomulya, Cordelia.

In: International Journal of Pharmaceutics, Vol. 570, 118654, 30.10.2019.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chakraborty, Amlan

AU - Royce, Simon G.

AU - Plebanski, Magdalena

AU - Selomulya, Cordelia

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