Glycation in diabetic nephropathy

Josephine M. Forbes, Mark E. Cooper

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D. With diabetes, many of these integral processes are interrupted via a combination of haemodynamic and metabolic changes including increases in the accumulation of proteins modified by advanced glycation, known as advanced glycation end products (AGEs). Indeed, hyperglycaemia and the redox imbalances seen with diabetes are each independent accelerants for the production of AGEs, which synergistically combine in this disorder. In addition, as kidney function declines, characterised by a loss of glomerular filtration, the excretion of AGEs is decreased, possibly exacerbating renal injury by further elevating the body's tissue and circulating AGE pool. Therefore, it has become apparent that decreasing the accumulation of AGEs or interrupting their downstream effects on the kidney, are desirable therapeutic targets for the treatment of diabetic renal disease. 

Original languageEnglish
Pages (from-to)1185-1192
Number of pages8
JournalAmino Acids
Volume42
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Advanced glycation
  • Diabetic nephropathy
  • Haemodynamic
  • Renal

Cite this

Forbes, Josephine M. ; Cooper, Mark E. / Glycation in diabetic nephropathy. In: Amino Acids. 2012 ; Vol. 42, No. 4. pp. 1185-1192.
@article{24aa6435df4948d0a562ccc45b29fe47,
title = "Glycation in diabetic nephropathy",
abstract = "The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D. With diabetes, many of these integral processes are interrupted via a combination of haemodynamic and metabolic changes including increases in the accumulation of proteins modified by advanced glycation, known as advanced glycation end products (AGEs). Indeed, hyperglycaemia and the redox imbalances seen with diabetes are each independent accelerants for the production of AGEs, which synergistically combine in this disorder. In addition, as kidney function declines, characterised by a loss of glomerular filtration, the excretion of AGEs is decreased, possibly exacerbating renal injury by further elevating the body's tissue and circulating AGE pool. Therefore, it has become apparent that decreasing the accumulation of AGEs or interrupting their downstream effects on the kidney, are desirable therapeutic targets for the treatment of diabetic renal disease. ",
keywords = "Advanced glycation, Diabetic nephropathy, Haemodynamic, Renal",
author = "Forbes, {Josephine M.} and Cooper, {Mark E.}",
year = "2012",
month = "4",
doi = "10.1007/s00726-010-0771-4",
language = "English",
volume = "42",
pages = "1185--1192",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer-Verlag London Ltd.",
number = "4",

}

Glycation in diabetic nephropathy. / Forbes, Josephine M.; Cooper, Mark E.

In: Amino Acids, Vol. 42, No. 4, 04.2012, p. 1185-1192.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Glycation in diabetic nephropathy

AU - Forbes, Josephine M.

AU - Cooper, Mark E.

PY - 2012/4

Y1 - 2012/4

N2 - The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D. With diabetes, many of these integral processes are interrupted via a combination of haemodynamic and metabolic changes including increases in the accumulation of proteins modified by advanced glycation, known as advanced glycation end products (AGEs). Indeed, hyperglycaemia and the redox imbalances seen with diabetes are each independent accelerants for the production of AGEs, which synergistically combine in this disorder. In addition, as kidney function declines, characterised by a loss of glomerular filtration, the excretion of AGEs is decreased, possibly exacerbating renal injury by further elevating the body's tissue and circulating AGE pool. Therefore, it has become apparent that decreasing the accumulation of AGEs or interrupting their downstream effects on the kidney, are desirable therapeutic targets for the treatment of diabetic renal disease. 

AB - The kidney is an extremely complex organ with broad ranging functions in the body, including but not restricted to waste excretion, ion and water balance, maintenance of blood pressure, glucose homeostasis, generation of erythropoietin and activation of vitamin D. With diabetes, many of these integral processes are interrupted via a combination of haemodynamic and metabolic changes including increases in the accumulation of proteins modified by advanced glycation, known as advanced glycation end products (AGEs). Indeed, hyperglycaemia and the redox imbalances seen with diabetes are each independent accelerants for the production of AGEs, which synergistically combine in this disorder. In addition, as kidney function declines, characterised by a loss of glomerular filtration, the excretion of AGEs is decreased, possibly exacerbating renal injury by further elevating the body's tissue and circulating AGE pool. Therefore, it has become apparent that decreasing the accumulation of AGEs or interrupting their downstream effects on the kidney, are desirable therapeutic targets for the treatment of diabetic renal disease. 

KW - Advanced glycation

KW - Diabetic nephropathy

KW - Haemodynamic

KW - Renal

UR - http://www.scopus.com/inward/record.url?scp=84862654886&partnerID=8YFLogxK

U2 - 10.1007/s00726-010-0771-4

DO - 10.1007/s00726-010-0771-4

M3 - Review Article

VL - 42

SP - 1185

EP - 1192

JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 4

ER -