Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control

Neil Orford, Michael John Bailey, Kirsi-Maija Kaukonen, Tania Elderkin, Peter Stow, Claire Cattigan, Mark Kotowicz, Rinaldo Bellomo

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2 Citations (Scopus)


This retrospective observational cohort study compared glycaemic control and long-term outcomes following transition from a modified intensive insulin therapy (mIIT) regimen to conventional glycaemic control (CGC) in adult patients admitted to a tertiary adult general intensive care unit, during two 24-month periods, before and after the publication of the Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation (NICE-SUGAR) trial. The before NICE-SUGAR cohort received mIIT (target glycaemic ranges 4.4 to 7.0 mmol/l), while the after NICE-SUGAR cohort received CGC (target glycaemic range 7.1 to 9.0 mmol/l). A total of 5202 patients were included in the study. With transition from mIIT to CGC, the mean time-weighted glucose increased from 6.94 mmol/l to 8.2 mmol/l (P
Original languageEnglish
Pages (from-to)239 - 247
Number of pages9
JournalAnaesthesia and Intensive Care
Issue number2
Publication statusPublished - 2014

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