Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control

Neil Orford, Michael John Bailey, Kirsi-Maija Kaukonen, Tania Elderkin, Peter Stow, Claire Cattigan, Mark Kotowicz, Rinaldo Bellomo

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

This retrospective observational cohort study compared glycaemic control and long-term outcomes following transition from a modified intensive insulin therapy (mIIT) regimen to conventional glycaemic control (CGC) in adult patients admitted to a tertiary adult general intensive care unit, during two 24-month periods, before and after the publication of the Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation (NICE-SUGAR) trial. The before NICE-SUGAR cohort received mIIT (target glycaemic ranges 4.4 to 7.0 mmol/l), while the after NICE-SUGAR cohort received CGC (target glycaemic range 7.1 to 9.0 mmol/l). A total of 5202 patients were included in the study. With transition from mIIT to CGC, the mean time-weighted glucose increased from 6.94 mmol/l to 8.2 mmol/l (P
Original languageEnglish
Pages (from-to)239 - 247
Number of pages9
JournalAnaesthesia and intensive care
Volume42
Issue number2
Publication statusPublished - 2014

Cite this

@article{803ab4192bca412c875017e8bb42b3a1,
title = "Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control",
abstract = "This retrospective observational cohort study compared glycaemic control and long-term outcomes following transition from a modified intensive insulin therapy (mIIT) regimen to conventional glycaemic control (CGC) in adult patients admitted to a tertiary adult general intensive care unit, during two 24-month periods, before and after the publication of the Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation (NICE-SUGAR) trial. The before NICE-SUGAR cohort received mIIT (target glycaemic ranges 4.4 to 7.0 mmol/l), while the after NICE-SUGAR cohort received CGC (target glycaemic range 7.1 to 9.0 mmol/l). A total of 5202 patients were included in the study. With transition from mIIT to CGC, the mean time-weighted glucose increased from 6.94 mmol/l to 8.2 mmol/l (P",
author = "Neil Orford and Bailey, {Michael John} and Kirsi-Maija Kaukonen and Tania Elderkin and Peter Stow and Claire Cattigan and Mark Kotowicz and Rinaldo Bellomo",
year = "2014",
language = "English",
volume = "42",
pages = "239 -- 247",
journal = "Anaesthesia and intensive care",
issn = "0310-057X",
publisher = "Australian Society of Anaesthetists (ASA)",
number = "2",

}

Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control. / Orford, Neil; Bailey, Michael John; Kaukonen, Kirsi-Maija; Elderkin, Tania; Stow, Peter; Cattigan, Claire; Kotowicz, Mark; Bellomo, Rinaldo.

In: Anaesthesia and intensive care, Vol. 42, No. 2, 2014, p. 239 - 247.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Glycaemic control and long-term outcomes following transition from modified intensive insulin therapy to conventional glycaemic control

AU - Orford, Neil

AU - Bailey, Michael John

AU - Kaukonen, Kirsi-Maija

AU - Elderkin, Tania

AU - Stow, Peter

AU - Cattigan, Claire

AU - Kotowicz, Mark

AU - Bellomo, Rinaldo

PY - 2014

Y1 - 2014

N2 - This retrospective observational cohort study compared glycaemic control and long-term outcomes following transition from a modified intensive insulin therapy (mIIT) regimen to conventional glycaemic control (CGC) in adult patients admitted to a tertiary adult general intensive care unit, during two 24-month periods, before and after the publication of the Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation (NICE-SUGAR) trial. The before NICE-SUGAR cohort received mIIT (target glycaemic ranges 4.4 to 7.0 mmol/l), while the after NICE-SUGAR cohort received CGC (target glycaemic range 7.1 to 9.0 mmol/l). A total of 5202 patients were included in the study. With transition from mIIT to CGC, the mean time-weighted glucose increased from 6.94 mmol/l to 8.2 mmol/l (P

AB - This retrospective observational cohort study compared glycaemic control and long-term outcomes following transition from a modified intensive insulin therapy (mIIT) regimen to conventional glycaemic control (CGC) in adult patients admitted to a tertiary adult general intensive care unit, during two 24-month periods, before and after the publication of the Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation (NICE-SUGAR) trial. The before NICE-SUGAR cohort received mIIT (target glycaemic ranges 4.4 to 7.0 mmol/l), while the after NICE-SUGAR cohort received CGC (target glycaemic range 7.1 to 9.0 mmol/l). A total of 5202 patients were included in the study. With transition from mIIT to CGC, the mean time-weighted glucose increased from 6.94 mmol/l to 8.2 mmol/l (P

UR - http://www.ncbi.nlm.nih.gov/pubmed/24580391

M3 - Article

VL - 42

SP - 239

EP - 247

JO - Anaesthesia and intensive care

JF - Anaesthesia and intensive care

SN - 0310-057X

IS - 2

ER -