Gluten sensitivity without coeliac disease - a new twist

Simone Louise Peters, Jane Grey Muir, Peter Raymond Gibson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Gluten-containing products are often blamed for contributing to various gastrointestinal and extraintestinal symptoms. While coeliac disease is a well-established entity, our understanding of non-coeliac gluten sensitivity (NCGS) is limited. Issues confounding progress in NCGS include the limited recognition of dietary components that often co-exist with gluten that might be triggering symptoms, lack of understanding of the mechanisms by which gluten might induce problems, and problems with clinical trial design and subsequent interpretation of results. A recent controlled trial using gold-standard elimination-rechallenge methodology in patients with self-reported NCGS has failed to confirm a gluten-specific effect on gastrointestinal symptoms. Furthermore, mechanisms by which gluten triggers symptoms remain unidentified. It is suggested that patients with suspected NCGS should explore other dietary triggers before exploring the gluten-free diet as an option.
Original languageEnglish
Pages (from-to)38 - 42
Number of pages5
JournalAgro Food Industry Hi-Tech
Volume25
Issue number2
Publication statusPublished - 2014

Cite this

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abstract = "Gluten-containing products are often blamed for contributing to various gastrointestinal and extraintestinal symptoms. While coeliac disease is a well-established entity, our understanding of non-coeliac gluten sensitivity (NCGS) is limited. Issues confounding progress in NCGS include the limited recognition of dietary components that often co-exist with gluten that might be triggering symptoms, lack of understanding of the mechanisms by which gluten might induce problems, and problems with clinical trial design and subsequent interpretation of results. A recent controlled trial using gold-standard elimination-rechallenge methodology in patients with self-reported NCGS has failed to confirm a gluten-specific effect on gastrointestinal symptoms. Furthermore, mechanisms by which gluten triggers symptoms remain unidentified. It is suggested that patients with suspected NCGS should explore other dietary triggers before exploring the gluten-free diet as an option.",
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Gluten sensitivity without coeliac disease - a new twist. / Peters, Simone Louise; Muir, Jane Grey; Gibson, Peter Raymond.

In: Agro Food Industry Hi-Tech, Vol. 25, No. 2, 2014, p. 38 - 42.

Research output: Contribution to journalArticleResearchpeer-review

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AB - Gluten-containing products are often blamed for contributing to various gastrointestinal and extraintestinal symptoms. While coeliac disease is a well-established entity, our understanding of non-coeliac gluten sensitivity (NCGS) is limited. Issues confounding progress in NCGS include the limited recognition of dietary components that often co-exist with gluten that might be triggering symptoms, lack of understanding of the mechanisms by which gluten might induce problems, and problems with clinical trial design and subsequent interpretation of results. A recent controlled trial using gold-standard elimination-rechallenge methodology in patients with self-reported NCGS has failed to confirm a gluten-specific effect on gastrointestinal symptoms. Furthermore, mechanisms by which gluten triggers symptoms remain unidentified. It is suggested that patients with suspected NCGS should explore other dietary triggers before exploring the gluten-free diet as an option.

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