Glutathione peroxidase 4: A new player in neurodegeneration?

B. R. Cardoso, D. J. Hare, A. I. Bush, B. R. Roberts

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)

Abstract

Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity. We review recent studies of GPx4 with an emphasis on neuronal protection, and discuss the relevance of selenium levels on its enzymatic activity.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalMolecular Psychiatry
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

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