Glutathione peroxidase-1 contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic mouse in response to ischemia/reperfusion injury

Peter J. Crack, Juliet M. Taylor, Judy B. De Haan, Ismail Kola, Paul Hertzog, Rocco C. Iannello

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Abstract

The authors hypothesized that glutathione peroxidase-1 (Gpx-1) contributes to the neuroprotection seen in the superoxide dismutase-1 transgenic (Sod-1 tg) mouse. To investigate this hypothesis, they crossed the Gpx-1 -/- mouse with the Sod-1 tg and subjected the cross to a mouse model of ischemia/reperfusion. Two hours of focal cerebral ischemia followed by 24 hours of reperfusion was induced via intraluminal suture. The Sod-1 tg/Gpx-1 -/- cross exhibited no neuroprotection when infarct volume was measured; indeed, infarct volume increased in the Sod-1 tg/Gpx-1 -/- cross compared with the wild-type mouse. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to ischemia/reperfusion injury.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalJournal of Cerebral Blood Flow and Metabolism
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2003

Keywords

  • Cerebral ischemia
  • Glutathione peroxidase-1
  • Knockout mouse
  • Oxidative stress
  • Superoxide dismutase

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