Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

Olivia Dean, Ashley I. Bush, Michael Berk, David L. Copolov, Maarten van den Buuse

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    Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses.

    Original languageEnglish
    Pages (from-to)258-262
    Number of pages5
    JournalBehavioural Brain Research
    Issue number1
    Publication statusPublished - 2 Mar 2009


    • 2-Cyclohexene-1-one
    • Animal model
    • Bipolar disorder
    • Cognition
    • Glutathione
    • Oxidative stress
    • Schizophrenia
    • Y-maze

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