Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

Olivia Dean; Ashley I. Bush; Michael Berk; David L. Copolov; Maarten van den Buuse

doi:10.1016/j.bbr.2008.11.017

Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

Olivia Dean, Ashley I. Bush, Michael Berk, David L. Copolov, Maarten van den Buuse

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Abstract

Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses.

Original language	English
Pages (from-to)	258-262
Number of pages	5
Journal	Behavioural Brain Research
Volume	198
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2008.11.017
Publication status	Published - 2 Mar 2009

Keywords

2-Cyclohexene-1-one
Animal model
Bipolar disorder
Cognition
Glutathione
Oxidative stress
Schizophrenia
Y-maze

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10.1016/j.bbr.2008.11.017

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abstract = "Oxidative stress and reduced brain glutathione (GSH) levels have been reported in psychiatric illnesses including schizophrenia and bipolar disorder. However the role of GSH in cognitive impairment in the illness remains unclear. Treatment of Sprague-Dawley rats and C57Bl/6 mice with 2-cyclohexene-1-one (CHX) dose-dependently reduced striatal and frontal cortical GSH levels similar to those in schizophrenia. In both species, GSH depletion resulted in disruption of short-term spatial recognition memory in a Y-maze test. In conclusion, GSH depletion induces cognitive impairment, which may be relevant to the role of GSH in psychiatric illnesses.",

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Glutathione depletion in the brain disrupts short-term spatial memory in the Y-maze in rats and mice

Abstract

Keywords

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