Glutamate Receptors, Metabotropic

K. J. Gregory, P. J. Conn

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

1 Citation (Scopus)


In addition to eliciting fast excitatory synaptic responses, the neurotransmitter glutamate can modulate neuronal excitability, synaptic transmission, and other cell functions by activation of a family of G protein-coupled receptors termed metabotropic glutamate (mGlu) receptors. Because of the ubiquitous distribution of glutamatergic synapses and the broad range of functions of the mGlu receptors, members of this receptor family participate in a broad range of functions of the central nervous system. As such, mGlu receptors are an attractive target for therapeutic intervention for a number of neurological and psychiatric disorders including Alzheimer's disease, Parkinson's disease, schizophrenia, anxiety, and depression.

Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherAcademic Press
Number of pages4
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
Publication statusPublished - 15 Feb 2013
Externally publishedYes


  • Allosteric
  • G protein
  • G protein-coupled receptor (GPCR)
  • Glutamate
  • Neuromodulation
  • Neurotransmitter
  • Orthosteric
  • Synaptic transmission

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