Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Pil Seok Chae, Rohini R. Rana, Kamil Gotfryd, Søren G F Rasmussen, Andrew C. Kruse, Kyung Ho Cho, Stefano Capaldi, Emil Carlsson, Brian Kobilka, Claus J. Loland, Ulrik Gether, Surajit Banerjee, Bernadette Byrne, John K. Lee, Samuel H. Gellman

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)


The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Original languageEnglish
Pages (from-to)2287-2289
Number of pages3
JournalChemical Communications
Issue number23
Publication statusPublished - 21 Mar 2013
Externally publishedYes

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