Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

Elaine Vicky Beaulieu, Devi Ngo, Leilani Llanes Santos, Yuan Hang Yang, Malcolm D Smith, Christian Jorgensen, Virginie Escriou, Daniel Scherman, Gabriel Courties, Florence Apparailly, Eric Morand

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Abstract

OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.
Original languageEnglish
Pages (from-to)2651 - 2661
Number of pages11
JournalArthritis & Rheumatism
Volume62
Issue number9
Publication statusPublished - 2010

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