TY - JOUR
T1 - Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis
AU - Beaulieu, Elaine Vicky
AU - Ngo, Devi
AU - Santos, Leilani Llanes
AU - Yang, Yuan Hang
AU - Smith, Malcolm D
AU - Jorgensen, Christian
AU - Escriou, Virginie
AU - Scherman, Daniel
AU - Courties, Gabriel
AU - Apparailly, Florence
AU - Morand, Eric
PY - 2010
Y1 - 2010
N2 - OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.
AB - OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.
M3 - Article
VL - 62
SP - 2651
EP - 2661
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 9
ER -