Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

Elaine Vicky Beaulieu; Devi Ngo; Leilani Llanes Santos; Yuan Hang Yang; Malcolm D Smith; Christian Jorgensen; Virginie Escriou; Daniel Scherman; Gabriel Courties; Florence Apparailly; Eric Morand

Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

Elaine Vicky Beaulieu, Devi Ngo, Leilani Llanes Santos, Yuan Hang Yang, Malcolm D Smith, Christian Jorgensen, Virginie Escriou, Daniel Scherman, Gabriel Courties, Florence Apparailly, Eric Morand

Research output: Contribution to journal › Article › Research › peer-review

68 Citations (Scopus)

Abstract

OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.

Original language	English
Pages (from-to)	2651 - 2661
Number of pages	11
Journal	Arthritis & Rheumatism
Volume	62
Issue number	9
Publication status	Published - 2010

Cite this

Beaulieu, Elaine Vicky ; Ngo, Devi ; Santos, Leilani Llanes ; Yang, Yuan Hang ; Smith, Malcolm D ; Jorgensen, Christian ; Escriou, Virginie ; Scherman, Daniel ; Courties, Gabriel ; Apparailly, Florence ; Morand, Eric. / Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis. In: Arthritis & Rheumatism. 2010 ; Vol. 62, No. 9. pp. 2651 - 2661.

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title = "Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis",

abstract = "OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.",

author = "Beaulieu, {Elaine Vicky} and Devi Ngo and Santos, {Leilani Llanes} and Yang, {Yuan Hang} and Smith, {Malcolm D} and Christian Jorgensen and Virginie Escriou and Daniel Scherman and Gabriel Courties and Florence Apparailly and Eric Morand",

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volume = "62",

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journal = "Arthritis & Rheumatology",

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Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis. / Beaulieu, Elaine Vicky; Ngo, Devi; Santos, Leilani Llanes; Yang, Yuan Hang; Smith, Malcolm D; Jorgensen, Christian; Escriou, Virginie; Scherman, Daniel; Courties, Gabriel; Apparailly, Florence; Morand, Eric.

In: Arthritis & Rheumatism, Vol. 62, No. 9, 2010, p. 2651 - 2661.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

AU - Beaulieu, Elaine Vicky

AU - Ngo, Devi

AU - Santos, Leilani Llanes

AU - Yang, Yuan Hang

AU - Smith, Malcolm D

AU - Jorgensen, Christian

AU - Escriou, Virginie

AU - Scherman, Daniel

AU - Courties, Gabriel

AU - Apparailly, Florence

AU - Morand, Eric

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.

AB - OBJECTIVE: Glucocorticoid-induced leucine zipper (GILZ) is a glucocorticoid-induced protein, the reported molecular interactions of which suggest that it functions to inhibit inflammation. However, the role of endogenous GILZ in the regulation of inflammation in vivo has not been established. This study was undertaken to examine the expression and function of GILZ in vivo in collagen-induced arthritis (CIA), a murine model of rheumatoid arthritis (RA), and in RA synoviocytes.

M3 - Article

VL - 62

SP - 2651

EP - 2661

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

SN - 2326-5191

IS - 9

ER -