Glucagonoma Masquerading as a Mucinous Cancer of the Ovary: Lessons from Cell Biology

Gwo-Yaw Ho, Sumitra S Ananda, Cassandra J Vandenberg, Orla M McNally, Jeanne Tie, Kylie Louise Gorringe, David D L Bowtell, Jan M Pyman, Matthew J Wakefield, Clare L Scott

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research

Abstract

High-grade mucinous ovarian cancer (HGMOC) is often a misnomer as the majority of cases are metastatic disease with a gastro-intestinal origin. The standard platinum-based ovarian cancer (OC) chemotherapy regimens are often ineffective, and there are insufficient data to support the use of colorectal cancer (CRC) chemotherapy regimens due to the rarity of HGMOC. We described a cohort of four consecutive suspected HGMOC cases treated at the Royal Women’s Hospital, Melbourne in 2012. Two cases were treated as primary MOC, whereas the other two were considered to be metastatic CRC based on histopathological and clinical evidence. From the RNAseq analysis, we identified two cases of HGMOC whose gene expression profiles were consistent with mucinous epithelial OC, one case that was treated as metastatic CRC with gene expression profile correlated with CRC and one case with neuroendocrine (NET) gene expression features. Interestingly, glucagon was over-expressed in this tumor that was subsequently confirmed by immunohistochemistry. These findings suggest a rare glucagonoma-like NET appendiceal tumor that had metastasized to the surface of ovary and were unresponsive to CRC chemotherapy regimens. In summary, a carefully curated panel of expression markers and selected functional genomics could provide diagnosis and treatment guidance for patients with possible HGMOC.
Original languageEnglish
Title of host publicationGynaecological Malignancies
Subtitle of host publicationUpdates and Advances
EditorsGwo Yaw Ho, Sophia Frentzas
PublisherIn-Tech
Pages1-15
Number of pages15
ISBN (Electronic)9781838802790, 9781838803063
ISBN (Print)9781838803056
DOIs
Publication statusPublished - 17 Jun 2020

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