Global collaboration between platform trials in surgery and anaesthesia

James Glasbey; Steve A. Webb; Trisha Peel; Thomas D. Pinkney; Paul S. Myles

doi:10.1093/bjs/znae262

Global collaboration between platform trials in surgery and anaesthesia

James Glasbey
, Steve A. Webb
, Trisha Peel
, Thomas D. Pinkney
, Paul S. Myles

Research output: Contribution to journal › Editorial › Other › peer-review

1 Citation (Scopus)

Abstract

Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

Original language	English
Article number	znae262
Number of pages	4
Journal	British Journal of Surgery
Volume	111
Issue number	12
DOIs	https://doi.org/10.1093/bjs/znae262
Publication status	Published - Dec 2024

Keywords

adaptive trials
anaesthesia
collaborative research
perioperative care
platform trials
surgery
surgical site infection

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10.1093/bjs/znae262Licence: CC BY

Cite this

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title = "Global collaboration between platform trials in surgery and anaesthesia",

abstract = "Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.",

keywords = "adaptive trials, anaesthesia, collaborative research, perioperative care, platform trials, surgery, surgical site infection",

author = "James Glasbey and Webb, \{Steve A.\} and Trisha Peel and Pinkney, \{Thomas D.\} and Myles, \{Paul S.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s) published by Oxford University Press on behalf of BJS Foundation Ltd and published by Elsevier Ltd on behalf of British Journal of Anaesthesia Society.",

year = "2024",

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AU - Glasbey, James

AU - Webb, Steve A.

AU - Peel, Trisha

AU - Pinkney, Thomas D.

AU - Myles, Paul S.

PY - 2024/12

Y1 - 2024/12

N2 - Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

AB - Large, randomized trials are the bedrock of evidence-based medicine, but the resources required to complete such trials greatly limit the number of important clinical questions that can be addressed within a reasonable period of time. Adaptive platform trials can identify effective, ineffective, or harmful treatments faster. These trials have been shown to deliver rapid evidence through the COVID-19 pandemic and are now being adopted across surgery and anaesthesia, with many opportunities for surgeons, anaesthetists, and other perioperative physicians to conduct and collaborate in platform trials.

KW - adaptive trials

KW - anaesthesia

KW - collaborative research

KW - perioperative care

KW - platform trials

KW - surgery

KW - surgical site infection

UR - https://www.scopus.com/pages/publications/85213042494

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JF - British Journal of Surgery

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M1 - znae262

ER -

Global collaboration between platform trials in surgery and anaesthesia

Abstract

Keywords

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