GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?

Laura Elizabeth Eades, Angeline Sharmila Thiagarajah, James Harris, Sarah A Jones, Eric Francis Morand, Michelle Theresa Leech

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.
Original languageEnglish
Pages (from-to)747 - 751
Number of pages5
JournalImmunology and Cell Biology
Volume92
Issue number9
DOIs
Publication statusPublished - 2014

Cite this

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title = "GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?",
abstract = "The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.",
author = "Eades, {Laura Elizabeth} and Thiagarajah, {Angeline Sharmila} and James Harris and Jones, {Sarah A} and Morand, {Eric Francis} and Leech, {Michelle Theresa}",
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GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis? / Eades, Laura Elizabeth; Thiagarajah, Angeline Sharmila; Harris, James; Jones, Sarah A; Morand, Eric Francis; Leech, Michelle Theresa.

In: Immunology and Cell Biology, Vol. 92, No. 9, 2014, p. 747 - 751.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?

AU - Eades, Laura Elizabeth

AU - Thiagarajah, Angeline Sharmila

AU - Harris, James

AU - Jones, Sarah A

AU - Morand, Eric Francis

AU - Leech, Michelle Theresa

PY - 2014

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AB - The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.

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