TY - JOUR
T1 - GILZ: a new link between the hypothalamic pituitary adrenal axis and rheumatoid arthritis?
AU - Eades, Laura Elizabeth
AU - Thiagarajah, Angeline Sharmila
AU - Harris, James
AU - Jones, Sarah A
AU - Morand, Eric Francis
AU - Leech, Michelle Theresa
PY - 2014
Y1 - 2014
N2 - The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.
AB - The hypothalamic-pituitary-adrenal (HPA) axis is an important regulator of the stress response. In healthy individuals, the HPA axis maintains an equilibrium, ensuring that endogenous glucocorticoid (GC) levels remain within the normal range. However, hypofunction of the HPA axis may have a role in the development of inflammatory diseases, such as rheumatoid arthritis (RA). Glucocorticoid-induced leucine zipper (GILZ) is an anti-inflammatory protein, the expression of which is upregulated by GC. Although GILZ mediates the anti-inflammatory effects of GC, it may not be associated with the adverse effects that are frequently caused by exogenous GC administration. This has raised interest in GILZ potentiation as a therapeutic approach in diseases such as RA, which may mimic the anti-inflammatory effects of GC without causing harmful side effects. This review will outline the involvement of the HPA axis in RA, as a prelude to highlighting emerging evidence regarding the role of GILZ in inflammation control and RA.
UR - http://www.nature.com/icb/journal/v92/n9/pdf/icb201456a.pdf
U2 - 10.1038/icb.2014.56
DO - 10.1038/icb.2014.56
M3 - Article
SN - 0818-9641
VL - 92
SP - 747
EP - 751
JO - Immunology and Cell Biology
JF - Immunology and Cell Biology
IS - 9
ER -