Ghrelin

Timo D Muller; Ruben Nogueiras; Mark L Andermann; Zane B Andrews; Stefan D Anker; Jesus Argente; Rachel L Batterham; S C Benoit; Cyril Y Bowers; Fabio Broglio; Felipe F Casanueva; D A D'Alessio; Inge Depoortere; Allan Geliebter; Ezio Ghigo; Philip A Cole; Michael A Cowley; David E Cummings; Alain Dagher; Sabrina Diano; Suzanne L Dickson; Carlos Dieguez; Riccarda Granata; Harvey J Grill; Kevin L Grove; Kirk M Habegger; Kristy Heppner; Mark L Heiman; Laura M Holsen; Birgitte Holst; Akio Inui; John-Olov Jansson; Henriette Kirchner; Marta Korbonits; Blandine Laferrere; Carel W Le Roux; Miguel Lopez; Silke Morin; Masamitsu Nakazato; Ralf M Nass; Diego Perez-Tilve; Paul T Pfluger; Thue W Schwartz; Randy J Seeley; Mark Sleeman; Yuxiang Sun; Lori G Sussel; Jenny Tong; Michael O Thorner; Aart J van der Lely; Lex H T Van der Ploeg; Jeffrey M Zigman; Masayasu Kojima; Kenji Kangawa; Roy G Smith; Tamas L Horvath; Matthias H Tschop

doi:10.1016/j.molmet.2015.03.005

Ghrelin

Timo D Muller, Ruben Nogueiras, Mark L Andermann, Zane B Andrews, Stefan D Anker, Jesus Argente, Rachel L Batterham, S C Benoit, Cyril Y Bowers, Fabio Broglio, Felipe F Casanueva, D A D'Alessio, Inge Depoortere, Allan Geliebter, Ezio Ghigo, Philip A Cole, Michael A Cowley, David E Cummings, Alain Dagher, Sabrina DianoSuzanne L Dickson, Carlos Dieguez, Riccarda Granata, Harvey J Grill, Kevin L Grove, Kirk M Habegger, Kristy Heppner, Mark L Heiman, Laura M Holsen, Birgitte Holst, Akio Inui, John-Olov Jansson, Henriette Kirchner, Marta Korbonits, Blandine Laferrere, Carel W Le Roux, Miguel Lopez, Silke Morin, Masamitsu Nakazato, Ralf M Nass, Diego Perez-Tilve, Paul T Pfluger, Thue W Schwartz, Randy J Seeley, Mark Sleeman, Yuxiang Sun, Lori G Sussel, Jenny Tong, Michael O Thorner, Aart J van der Lely, Lex H T Van der Ploeg, Jeffrey M Zigman, Masayasu Kojima, Kenji Kangawa, Roy G Smith, Tamas L Horvath, Matthias H Tschop

Physiology

Research output: Contribution to journal › Review Article › Research › peer-review

972 Citations (Scopus)

Abstract

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.
SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.
MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original language	English
Pages (from-to)	437 - 460
Number of pages	24
Journal	Molecular Metabolism
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/j.molmet.2015.03.005
Publication status	Published - 21 Mar 2015

Keywords

ghrelin
growth hormone secretagogue receptor

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10.1016/j.molmet.2015.03.005Licence: CC BY

2015000547-oaLicence: CC BY

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Muller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D. A., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M. A., Cummings, D. E., Dagher, A., ... Tschop, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437 - 460. https://doi.org/10.1016/j.molmet.2015.03.005

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abstract = "BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",

keywords = "ghrelin, growth hormone secretagogue receptor",

author = "Muller, \{Timo D\} and Ruben Nogueiras and Andermann, \{Mark L\} and Andrews, \{Zane B\} and Anker, \{Stefan D\} and Jesus Argente and Batterham, \{Rachel L\} and Benoit, \{S C\} and Bowers, \{Cyril Y\} and Fabio Broglio and Casanueva, \{Felipe F\} and D'Alessio, \{D A\} and Inge Depoortere and Allan Geliebter and Ezio Ghigo and Cole, \{Philip A\} and Cowley, \{Michael A\} and Cummings, \{David E\} and Alain Dagher and Sabrina Diano and Dickson, \{Suzanne L\} and Carlos Dieguez and Riccarda Granata and Grill, \{Harvey J\} and Grove, \{Kevin L\} and Habegger, \{Kirk M\} and Kristy Heppner and Heiman, \{Mark L\} and Holsen, \{Laura M\} and Birgitte Holst and Akio Inui and John-Olov Jansson and Henriette Kirchner and Marta Korbonits and Blandine Laferrere and \{Le Roux\}, \{Carel W\} and Miguel Lopez and Silke Morin and Masamitsu Nakazato and Nass, \{Ralf M\} and Diego Perez-Tilve and Pfluger, \{Paul T\} and Schwartz, \{Thue W\} and Seeley, \{Randy J\} and Mark Sleeman and Yuxiang Sun and Sussel, \{Lori G\} and Jenny Tong and Thorner, \{Michael O\} and \{van der Lely\}, \{Aart J\} and \{Van der Ploeg\}, \{Lex H T\} and Zigman, \{Jeffrey M\} and Masayasu Kojima and Kenji Kangawa and Smith, \{Roy G\} and Horvath, \{Tamas L\} and Tschop, \{Matthias H\}",

year = "2015",

month = mar,

day = "21",

doi = "10.1016/j.molmet.2015.03.005",

language = "English",

volume = "4",

pages = "437 -- 460",

journal = "Molecular Metabolism",

issn = "2212-8778",

publisher = "Elsevier",

number = "6",

}

Muller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, DA, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, MA, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Dieguez, C, Granata, R, Grill, HJ, Grove, KL, Habegger, KM, Heppner, K, Heiman, ML, Holsen, LM, Holst, B, Inui, A, Jansson, J-O, Kirchner, H, Korbonits, M, Laferrere, B, Le Roux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, RM, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, LG, Tong, J, Thorner, MO, van der Lely, AJ, Van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, TL & Tschop, MH 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437 - 460. https://doi.org/10.1016/j.molmet.2015.03.005

TY - JOUR

T1 - Ghrelin

AU - Muller, Timo D

AU - Nogueiras, Ruben

AU - Andermann, Mark L

AU - Andrews, Zane B

AU - Anker, Stefan D

AU - Argente, Jesus

AU - Batterham, Rachel L

AU - Benoit, S C

AU - Bowers, Cyril Y

AU - Broglio, Fabio

AU - Casanueva, Felipe F

AU - D'Alessio, D A

AU - Depoortere, Inge

AU - Geliebter, Allan

AU - Ghigo, Ezio

AU - Cole, Philip A

AU - Cowley, Michael A

AU - Cummings, David E

AU - Dagher, Alain

AU - Diano, Sabrina

AU - Dickson, Suzanne L

AU - Dieguez, Carlos

AU - Granata, Riccarda

AU - Grill, Harvey J

AU - Grove, Kevin L

AU - Habegger, Kirk M

AU - Heppner, Kristy

AU - Heiman, Mark L

AU - Holsen, Laura M

AU - Holst, Birgitte

AU - Inui, Akio

AU - Jansson, John-Olov

AU - Kirchner, Henriette

AU - Korbonits, Marta

AU - Laferrere, Blandine

AU - Le Roux, Carel W

AU - Lopez, Miguel

AU - Morin, Silke

AU - Nakazato, Masamitsu

AU - Nass, Ralf M

AU - Perez-Tilve, Diego

AU - Pfluger, Paul T

AU - Schwartz, Thue W

AU - Seeley, Randy J

AU - Sleeman, Mark

AU - Sun, Yuxiang

AU - Sussel, Lori G

AU - Tong, Jenny

AU - Thorner, Michael O

AU - van der Lely, Aart J

AU - Van der Ploeg, Lex H T

AU - Zigman, Jeffrey M

AU - Kojima, Masayasu

AU - Kangawa, Kenji

AU - Smith, Roy G

AU - Horvath, Tamas L

AU - Tschop, Matthias H

PY - 2015/3/21

Y1 - 2015/3/21

N2 - BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

AB - BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

KW - ghrelin

KW - growth hormone secretagogue receptor

UR - http://www.ncbi.nlm.nih.gov/pubmed/26042199

UR - https://www.scopus.com/pages/publications/84929964936

U2 - 10.1016/j.molmet.2015.03.005

DO - 10.1016/j.molmet.2015.03.005

M3 - Review Article

SN - 2212-8778

VL - 4

SP - 437

EP - 460

JO - Molecular Metabolism

JF - Molecular Metabolism

IS - 6

ER -

Ghrelin

Abstract

Keywords

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