Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men

Elisabeth Lambert; Gavin W Lambert; Caroline Ika-Sari; Tye Dawood; Katie Lee; Reena Chopra; Nora Straznicky; Nina Eikelis; Sara Drew; Alan J Tilbrook; John Dixon; Murray D Esler; Markus Schlaich

doi:10.1161/HYPERTENSIONAHA.111.171025

Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men

Elisabeth Lambert, Gavin W Lambert, Caroline Ika-Sari, Tye Dawood, Katie Lee, Reena Chopra, Nora Straznicky, Nina Eikelis, Sara Drew, Alan J Tilbrook, John Dixon, Murray D Esler, Markus Schlaich

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Abstract

Ghrelin is a growth hormone-releasing peptide secreted by the stomach with potent effects on appetite. Experimental and clinical studies indicate that ghrelin also influences cardiovascular regulation and metabolic function and mediates behavioral responses to stress. We investigated the effects of ghrelin on blood pressure (BP), sympathetic nervous system activity, and mental stress responses in lean (n=13) and overweight or obese (n=13) individuals. Subjects received an intravenous infusion of human ghrelin (5 pmol/kg per minute for 1 hour) and saline in a randomized fashion. Ghrelin decreased systolic (-6 and -11 mm Hg) and diastolic BP (-8 mm Hg for both), increased muscle sympathetic nervous system activity (18+/-2 to 28+/-3 bursts per min, P

Original language	English
Pages (from-to)	43 - 50
Number of pages	8
Journal	Hypertension
Volume	58
Issue number	1
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.111.171025
Publication status	Published - 2011

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10.1161/HYPERTENSIONAHA.111.171025

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title = "Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men",

abstract = "Ghrelin is a growth hormone-releasing peptide secreted by the stomach with potent effects on appetite. Experimental and clinical studies indicate that ghrelin also influences cardiovascular regulation and metabolic function and mediates behavioral responses to stress. We investigated the effects of ghrelin on blood pressure (BP), sympathetic nervous system activity, and mental stress responses in lean (n=13) and overweight or obese (n=13) individuals. Subjects received an intravenous infusion of human ghrelin (5 pmol/kg per minute for 1 hour) and saline in a randomized fashion. Ghrelin decreased systolic (-6 and -11 mm Hg) and diastolic BP (-8 mm Hg for both), increased muscle sympathetic nervous system activity (18+/-2 to 28+/-3 bursts per min, P",

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T1 - Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men

AU - Lambert, Elisabeth

AU - Lambert, Gavin W

AU - Ika-Sari, Caroline

AU - Dawood, Tye

AU - Lee, Katie

AU - Chopra, Reena

AU - Straznicky, Nora

AU - Eikelis, Nina

AU - Drew, Sara

AU - Tilbrook, Alan J

AU - Dixon, John

AU - Esler, Murray D

AU - Schlaich, Markus

PY - 2011

Y1 - 2011

N2 - Ghrelin is a growth hormone-releasing peptide secreted by the stomach with potent effects on appetite. Experimental and clinical studies indicate that ghrelin also influences cardiovascular regulation and metabolic function and mediates behavioral responses to stress. We investigated the effects of ghrelin on blood pressure (BP), sympathetic nervous system activity, and mental stress responses in lean (n=13) and overweight or obese (n=13) individuals. Subjects received an intravenous infusion of human ghrelin (5 pmol/kg per minute for 1 hour) and saline in a randomized fashion. Ghrelin decreased systolic (-6 and -11 mm Hg) and diastolic BP (-8 mm Hg for both), increased muscle sympathetic nervous system activity (18+/-2 to 28+/-3 bursts per min, P

AB - Ghrelin is a growth hormone-releasing peptide secreted by the stomach with potent effects on appetite. Experimental and clinical studies indicate that ghrelin also influences cardiovascular regulation and metabolic function and mediates behavioral responses to stress. We investigated the effects of ghrelin on blood pressure (BP), sympathetic nervous system activity, and mental stress responses in lean (n=13) and overweight or obese (n=13) individuals. Subjects received an intravenous infusion of human ghrelin (5 pmol/kg per minute for 1 hour) and saline in a randomized fashion. Ghrelin decreased systolic (-6 and -11 mm Hg) and diastolic BP (-8 mm Hg for both), increased muscle sympathetic nervous system activity (18+/-2 to 28+/-3 bursts per min, P

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DO - 10.1161/HYPERTENSIONAHA.111.171025

M3 - Article

SN - 0194-911X

VL - 58

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EP - 50

JO - Hypertension

JF - Hypertension

IS - 1

ER -

Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men

Abstract

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