Ghrelin modulates sympathetic nervous system activity and stress response in lean and overweight men

Elisabeth Lambert, Gavin W Lambert, Caroline Ika-Sari, Tye Dawood, Katie Lee, Reena Chopra, Nora Straznicky, Nina Eikelis, Sara Drew, Alan J Tilbrook, John Dixon, Murray D Esler, Markus Schlaich

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Abstract

Ghrelin is a growth hormone-releasing peptide secreted by the stomach with potent effects on appetite. Experimental and clinical studies indicate that ghrelin also influences cardiovascular regulation and metabolic function and mediates behavioral responses to stress. We investigated the effects of ghrelin on blood pressure (BP), sympathetic nervous system activity, and mental stress responses in lean (n=13) and overweight or obese (n=13) individuals. Subjects received an intravenous infusion of human ghrelin (5 pmol/kg per minute for 1 hour) and saline in a randomized fashion. Ghrelin decreased systolic (-6 and -11 mm Hg) and diastolic BP (-8 mm Hg for both), increased muscle sympathetic nervous system activity (18+/-2 to 28+/-3 bursts per min, P
Original languageEnglish
Pages (from-to)43 - 50
Number of pages8
JournalHypertension
Volume58
Issue number1
DOIs
Publication statusPublished - 2011

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