Ghrelin-induced adiposity is independent of orexigenic effects

Diego Perez-Tilve; Kristy Heppner; Henriette Kirchner; Sarah Kathleen Haas Lockie; Stephen Woods; David Smiley; Matthias Tschop; Paul Pfluger

doi:10.1096/fj.11-183632

Ghrelin-induced adiposity is independent of orexigenic effects

Diego Perez-Tilve, Kristy Heppner, Henriette Kirchner, Sarah Kathleen Haas Lockie, Stephen Woods, David Smiley, Matthias Tschop, Paul Pfluger

Physiology

Research output: Contribution to journal › Article › Research › peer-review

74 Citations (Scopus)

Abstract

Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 +/- 5 g (ghrelin+CD) vs. 152 +/- 5 g (control i.c.v. saline+CD), P

Original language	English
Pages (from-to)	2814 - 2822
Number of pages	9
Journal	The FASEB Journal
Volume	25
Issue number	8
DOIs	https://doi.org/10.1096/fj.11-183632
Publication status	Published - 2011

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10.1096/fj.11-183632

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Cite this

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title = "Ghrelin-induced adiposity is independent of orexigenic effects",

abstract = "Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 +/- 5 g (ghrelin+CD) vs. 152 +/- 5 g (control i.c.v. saline+CD), P",

author = "Diego Perez-Tilve and Kristy Heppner and Henriette Kirchner and Lockie, {Sarah Kathleen Haas} and Stephen Woods and David Smiley and Matthias Tschop and Paul Pfluger",

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T1 - Ghrelin-induced adiposity is independent of orexigenic effects

AU - Perez-Tilve, Diego

AU - Heppner, Kristy

AU - Kirchner, Henriette

AU - Lockie, Sarah Kathleen Haas

AU - Woods, Stephen

AU - Smiley, David

AU - Tschop, Matthias

AU - Pfluger, Paul

PY - 2011

Y1 - 2011

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AB - Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 +/- 5 g (ghrelin+CD) vs. 152 +/- 5 g (control i.c.v. saline+CD), P

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JF - The FASEB Journal

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