Ghrelin-induced adiposity is independent of orexigenic effects

Diego Perez-Tilve, Kristy Heppner, Henriette Kirchner, Sarah Kathleen Haas Lockie, Stephen Woods, David Smiley, Matthias Tschop, Paul Pfluger

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)


Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 +/- 5 g (ghrelin+CD) vs. 152 +/- 5 g (control i.c.v. saline+CD), P
Original languageEnglish
Pages (from-to)2814 - 2822
Number of pages9
JournalThe FASEB Journal
Issue number8
Publication statusPublished - 2011

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