Abstract
Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 +/- 5 g (ghrelin+CD) vs. 152 +/- 5 g (control i.c.v. saline+CD), P
Original language | English |
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Pages (from-to) | 2814 - 2822 |
Number of pages | 9 |
Journal | The FASEB Journal |
Volume | 25 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2011 |