Ghrelin

Timo D Muller, Ruben Nogueiras, Mark L Andermann, Zane B Andrews, Stefan D Anker, Jesus Argente, Rachel L Batterham, S C Benoit, Cyril Y Bowers, Fabio Broglio, Felipe F Casanueva, D A D'Alessio, Inge Depoortere, Allan Geliebter, Ezio Ghigo, Philip A Cole, Michael A Cowley, David E Cummings, Alain Dagher, Sabrina DianoSuzanne L Dickson, Carlos Dieguez, Riccarda Granata, Harvey J Grill, Kevin L Grove, Kirk M Habegger, Kristy Heppner, Mark L Heiman, Laura M Holsen, Birgitte Holst, Akio Inui, John-Olov Jansson, Henriette Kirchner, Marta Korbonits, Blandine Laferrere, Carel W Le Roux, Miguel Lopez, Silke Morin, Masamitsu Nakazato, Ralf M Nass, Diego Perez-Tilve, Paul T Pfluger, Thue W Schwartz, Randy J Seeley, Mark Sleeman, Yuxiang Sun, Lori G Sussel, Jenny Tong, Michael O Thorner, Aart J van der Lely, Lex H T Van der Ploeg, Jeffrey M Zigman, Masayasu Kojima, Kenji Kangawa, Roy G Smith, Tamas L Horvath, Matthias H Tschop

Research output: Contribution to journalReview ArticleResearchpeer-review

504 Citations (Scopus)

Abstract

BACKGROUND: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.
SCOPE OF REVIEW: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.
MAJOR CONCLUSIONS: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
Original languageEnglish
Pages (from-to)437 - 460
Number of pages24
JournalMolecular Metabolism
Volume4
Issue number6
DOIs
Publication statusPublished - 21 Mar 2015

Keywords

  • ghrelin
  • growth hormone secretagogue receptor

Cite this