Germline genetic contributions to risk for esophageal adenocarcinoma, barrett's esophagus, and gastroesophageal reflux

Weronica E. Ek, David M. Levine, Mauro D'Amato, Nancy L. Pedersen, Patrik K.E. Magnusson, Francesca Bresso, Lynn E. Onstad, Peter T. Schmidt, Hans Törnblom, Helena Nordenstedt, Yvonne Romero, Wong Ho Chow, Liam J. Murray, Marilie D. Gammon, Geoffrey Liu, Leslie Bernstein, Alan G. Casson, Harvey A. Risch, Nicholas J. Shaheen, Nigel C. BirdBrian J. Reid, Douglas A. Corley, Laura J. Hardie, Weimin Ye, Anna H. Wu, Marco Zucchelli, Tim D. Spector, Pirro Hysi, Thomas L. Vaughan, David C. Whiteman, Stuart MacGregor

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66 Citations (Scopus)

Abstract

Background Esophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA, and every year 0.12% to 0.5% of BE patients progress to EA. BE typically arises on a background of chronic gastroesophageal reflux (GERD), one of the risk factors for EA. Methods We used genome-wide association data to investigate the genetic architecture underlying GERD, BE, and EA. We applied a method to estimate the variance explained (array heritability, h2 g) and the genetic correlation (rg) between GERD, BE, and EA by considering all single nucleotide polymorphisms (SNPs) simultaneously. We also estimated the polygenic overlap between GERD, BE, and EA using a prediction approach. All tests were twosided, except in the case of variance-explained estimation where one-sided tests were used. Results We estimated a statistically significant genetic variance explained for BE (h2 g = 35%; standard error [SE] = 6%; one-sided P = 1 × 10-9) and for EA (h2 g = 25 %; SE = 5%; one-sided P = 2 × 10-7). The genetic correlation between BE and EA was found to be high (rg = 1.0; SE = 0.37). We also estimated a statistically significant polygenic overlap between BE and EA (one-sided P = 1 × 10-6), which suggests, together with the high genetic correlation, that shared genes underlie the development of BE and EA. Conversely, no statistically significant results were obtained for GERD. Conclusions We have demonstrated that risk to BE and EA is influenced by many germline genetic variants of small effect and that shared polygenic effects contribute to risk of these two diseases.

Original languageEnglish
Pages (from-to)1711-1718
Number of pages8
JournalJournal of the National Cancer Institute
Volume105
Issue number22
DOIs
Publication statusPublished - 20 Nov 2013
Externally publishedYes

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