Germ cell sex and cell cycle

Denise Miles, Patrick Western

    Research output: Contribution to journalArticleResearchpeer-review

    7 Citations (Scopus)

    Abstract

    Germ cells are the only cells in the body capable of transferring an individual s genetic and epigenetic information to the next generation. However, the developmental processes that provide the foundation for male and female germ line development and later gamete production are complex and poorly understood. In mice the primordial germ cells enter the bipotential gonad at E10.5 and, in response to the testicular or ovarian micro-environment, commit to spermatogenesis or oogenesis. This paper reviews progress in understanding the molecular processes underlying the early stages of male and female germ line development.
    Original languageEnglish
    Pages (from-to)445 - 457
    Number of pages13
    JournalHistology and Histopathology
    Volume27
    Issue number4
    Publication statusPublished - 2012

    Cite this

    Miles, Denise ; Western, Patrick. / Germ cell sex and cell cycle. In: Histology and Histopathology. 2012 ; Vol. 27, No. 4. pp. 445 - 457.
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    Miles, D & Western, P 2012, 'Germ cell sex and cell cycle', Histology and Histopathology, vol. 27, no. 4, pp. 445 - 457.

    Germ cell sex and cell cycle. / Miles, Denise; Western, Patrick.

    In: Histology and Histopathology, Vol. 27, No. 4, 2012, p. 445 - 457.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Western, Patrick

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    AB - Germ cells are the only cells in the body capable of transferring an individual s genetic and epigenetic information to the next generation. However, the developmental processes that provide the foundation for male and female germ line development and later gamete production are complex and poorly understood. In mice the primordial germ cells enter the bipotential gonad at E10.5 and, in response to the testicular or ovarian micro-environment, commit to spermatogenesis or oogenesis. This paper reviews progress in understanding the molecular processes underlying the early stages of male and female germ line development.

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