Projects per year
Abstract
Peptides comprised entirely of beta-amino acids, or beta-peptides, have attracted substantial interest over the past 25 years due to their unique structural and chemical characteristics. beta-Peptides form well-defined secondary structures that exhibit different geometries compared with their alpha-peptide counterparts, giving rise to their foldamer classification. beta-Peptide foldamers can be functionalized easily and are metabolically stable and, together with the predictable side-chain topography, have led to the design of a growing number of bioactive beta-peptides with a range of biological targets. The strategic engineering of chemical and topographic properties has also led to the design of beta-peptide mimics of higher-order oligomers. More recently, the ability of these peptides to self-assemble into complex structures of controlled geometries has been exploited in materials applications. The focus of this mini-review is on how the unique structural features of beta-peptide assemblies have been exploited in the design of self-assembled proteomimetic bundles and nanomaterials.
Original language | English |
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Pages (from-to) | 1417 - 1423 |
Number of pages | 7 |
Journal | Chemistry & Biology |
Volume | 22 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2015 |
Projects
- 1 Finished
-
The Design and Synthesis of Inhibitors of HIV Budding
Aguilar, M. (Primary Chief Investigator (PCI)) & Shenu-Xhilaga, M. (Chief Investigator (CI))
ARC - Australian Research Council
4/01/10 → 31/12/12
Project: Research