Genotype-guided warfarin therapy: Current status

Letícia C. Tavares, Leiliane R. Marcatto, Paulo C J L Santos

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Warfarin pharmacogenomics has been an extensively studied field in the last decades as it is focused on personalized therapy to overcome the wide interpatient warfarin response variability and decrease the risk of side effects. In this expert review, besides briefly summarizing the current knowledge about warfarin pharmacogenetics, we also present an overview of recent studies that aimed to assess the efficacy, safety and economic issues related to genotype-based dosing algorithms used to guide warfarin therapy, including randomized and controlled clinical trials, meta-analyses and cost-effectiveness studies. To date, the findings still present disparities, mostly because of standard limitations. Thus, further studies should be encouraged to try to demonstrate the benefits of the application of warfarin pharmacogenomic dosing algorithms in clinical practice.

Original languageEnglish
Pages (from-to)667-685
Number of pages19
JournalPharmacogenomics
Volume19
Issue number7
DOIs
Publication statusPublished - May 2018
Externally publishedYes

Keywords

  • genotype-guided dosing algorithms
  • pharmacogenetic-based algorithm
  • pharmacogenetics
  • polymorphisms
  • Vitamin K antagonist
  • warfarin

Cite this