Genomic insights into WNT/β-catenin signaling

Joseph Rosenbluh, Xiaoxing Wang, William C. Hahn

Research output: Contribution to journalReview ArticleOtherpeer-review

78 Citations (Scopus)

Abstract

The canonical WNT pathway regulates the stability of the proto-oncogene β-catenin and is aberrantly activated in many cancer types. Studies in a wide range of experimental models confirm that β-catenin activity is required for tumor initiation in cancers where this pathway is deregulated. However, to date this pathway has proven to be challenging to target therapeutically. Moreover, several lines of evidence suggest that other components and regulators of β-catenin exist. Here we will describe recent structural and functional studies describing genomic alterations and new regulators of β-catenin that lead to aberrant activation of the WNT/β-catenin pathway. These findings provide new insights into the biology of WNT/β-catenin signaling and suggest potential therapeutic opportunities.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalTrends in Pharmacological Sciences
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

Keywords

  • β-catenin
  • cancer
  • synthetic lethality
  • WNT
  • YAP1

Cite this