Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

Stephen Baker, Nicholas Thomson, François Xavier Weill, Kathryn E. Holt

Research output: Contribution to journalReview ArticleResearchpeer-review

87 Citations (Scopus)

Abstract

Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some antimicrobial resistant pathogens have outpaced us, with untreatable infections appearing in hospitals and the community. However, WGS has additionally provided us with enough knowledge to initiate countermeasures. Although we cannot stop bacterial adaptation, the predictability of many evolutionary processes in AMR bacteria offers us an opportunity to channel them using new control strategies. Furthermore, by using WGS for coordinating surveillance and to create a more fundamental understanding of the outcome of antimicrobial treatment and AMR mechanisms, we can use current and future antimicrobials more effectively and aim to extend their longevity.

Original languageEnglish
Pages (from-to)733-738
Number of pages6
JournalScience
Volume360
Issue number6390
DOIs
Publication statusPublished - 18 May 2018
Externally publishedYes

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