Genome wide conditional mouse knockout resources

C. Kaloff, Konstantinos Anastassiadis, A. Ayadi, R Baldock, J. Beig, M. C. Birling, A. Bradley, S. D.M. Brown, A. Bürger, W. Bushell, Francesco Chiani, F. S. Collins, Brendan Doe, J. T. Eppig, R. H. Finnell, Jennifer C Fletcher, Paul Flicek, Mirca El Fray, R. H. Friedel, A. Gambadoro & 46 others Hilary Gates, J. Hansen, Y. Herault, Gemma Hicks, A. Hörlein, M. Hrabé de Angelis, V. J. Iyer, P. J. de Jong, G. Koscielny, R. Kühn, P. Liu, K. C.K. Lloyd, R. G. Lopez, Jeffrey S. Marschall, S. Martínez, C. McKerlie, T. Meehan, H. von Melchner, M. Moore, S. A. Murray, A. Nagy, L. M.J. Nutter, G. Pavlovic, A. Pombero, H. Prosser, Ramiro Ramirez-Solis, Martin Ringwald, Barry Rosen, N. Rosenthal, Janet Rossant, P. Ruiz Noppinger, Ed Ryder, William C Skarnes, J. Schick, F. Schnütgen, P E Schofield, C. Seisenberger, M. Selloum, Damian P Smedley, E. M. Simpson, A. F. Stewart, Lydia Teboul, G. P. Tocchini Valentini, David M Valenzuela, A. P. West, W Wurst

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalDrug Discovery Today: Disease Models
Volume20
DOIs
Publication statusPublished - 2016
Externally publishedYes

Cite this

Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M. C., ... Wurst, W. (2016). Genome wide conditional mouse knockout resources. Drug Discovery Today: Disease Models, 20, 3-12. https://doi.org/10.1016/j.ddmod.2017.08.002
Kaloff, C. ; Anastassiadis, Konstantinos ; Ayadi, A. ; Baldock, R ; Beig, J. ; Birling, M. C. ; Bradley, A. ; Brown, S. D.M. ; Bürger, A. ; Bushell, W. ; Chiani, Francesco ; Collins, F. S. ; Doe, Brendan ; Eppig, J. T. ; Finnell, R. H. ; Fletcher, Jennifer C ; Flicek, Paul ; El Fray, Mirca ; Friedel, R. H. ; Gambadoro, A. ; Gates, Hilary ; Hansen, J. ; Herault, Y. ; Hicks, Gemma ; Hörlein, A. ; Hrabé de Angelis, M. ; Iyer, V. J. ; de Jong, P. J. ; Koscielny, G. ; Kühn, R. ; Liu, P. ; Lloyd, K. C.K. ; Lopez, R. G. ; Marschall, Jeffrey S. ; Martínez, S. ; McKerlie, C. ; Meehan, T. ; von Melchner, H. ; Moore, M. ; Murray, S. A. ; Nagy, A. ; Nutter, L. M.J. ; Pavlovic, G. ; Pombero, A. ; Prosser, H. ; Ramirez-Solis, Ramiro ; Ringwald, Martin ; Rosen, Barry ; Rosenthal, N. ; Rossant, Janet ; Ruiz Noppinger, P. ; Ryder, Ed ; Skarnes, William C ; Schick, J. ; Schnütgen, F. ; Schofield, P E ; Seisenberger, C. ; Selloum, M. ; Smedley, Damian P ; Simpson, E. M. ; Stewart, A. F. ; Teboul, Lydia ; Tocchini Valentini, G. P. ; Valenzuela, David M ; West, A. P. ; Wurst, W. / Genome wide conditional mouse knockout resources. In: Drug Discovery Today: Disease Models. 2016 ; Vol. 20. pp. 3-12.
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title = "Genome wide conditional mouse knockout resources",
abstract = "The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.",
author = "C. Kaloff and Konstantinos Anastassiadis and A. Ayadi and R Baldock and J. Beig and Birling, {M. C.} and A. Bradley and Brown, {S. D.M.} and A. B{\"u}rger and W. Bushell and Francesco Chiani and Collins, {F. S.} and Brendan Doe and Eppig, {J. T.} and Finnell, {R. H.} and Fletcher, {Jennifer C} and Paul Flicek and {El Fray}, Mirca and Friedel, {R. H.} and A. Gambadoro and Hilary Gates and J. Hansen and Y. Herault and Gemma Hicks and A. H{\"o}rlein and {Hrab{\'e} de Angelis}, M. and Iyer, {V. J.} and {de Jong}, {P. J.} and G. Koscielny and R. K{\"u}hn and P. Liu and Lloyd, {K. C.K.} and Lopez, {R. G.} and Marschall, {Jeffrey S.} and S. Mart{\'i}nez and C. McKerlie and T. Meehan and {von Melchner}, H. and M. Moore and Murray, {S. A.} and A. Nagy and Nutter, {L. M.J.} and G. Pavlovic and A. Pombero and H. Prosser and Ramiro Ramirez-Solis and Martin Ringwald and Barry Rosen and N. Rosenthal and Janet Rossant and {Ruiz Noppinger}, P. and Ed Ryder and Skarnes, {William C} and J. Schick and F. Schn{\"u}tgen and Schofield, {P E} and C. Seisenberger and M. Selloum and Smedley, {Damian P} and Simpson, {E. M.} and Stewart, {A. F.} and Lydia Teboul and {Tocchini Valentini}, {G. P.} and Valenzuela, {David M} and West, {A. P.} and W Wurst",
year = "2016",
doi = "10.1016/j.ddmod.2017.08.002",
language = "English",
volume = "20",
pages = "3--12",
journal = "Drug Discovery Today: Disease Models",
issn = "1740-6757",
publisher = "Elsevier",

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Kaloff, C, Anastassiadis, K, Ayadi, A, Baldock, R, Beig, J, Birling, MC, Bradley, A, Brown, SDM, Bürger, A, Bushell, W, Chiani, F, Collins, FS, Doe, B, Eppig, JT, Finnell, RH, Fletcher, JC, Flicek, P, El Fray, M, Friedel, RH, Gambadoro, A, Gates, H, Hansen, J, Herault, Y, Hicks, G, Hörlein, A, Hrabé de Angelis, M, Iyer, VJ, de Jong, PJ, Koscielny, G, Kühn, R, Liu, P, Lloyd, KCK, Lopez, RG, Marschall, JS, Martínez, S, McKerlie, C, Meehan, T, von Melchner, H, Moore, M, Murray, SA, Nagy, A, Nutter, LMJ, Pavlovic, G, Pombero, A, Prosser, H, Ramirez-Solis, R, Ringwald, M, Rosen, B, Rosenthal, N, Rossant, J, Ruiz Noppinger, P, Ryder, E, Skarnes, WC, Schick, J, Schnütgen, F, Schofield, PE, Seisenberger, C, Selloum, M, Smedley, DP, Simpson, EM, Stewart, AF, Teboul, L, Tocchini Valentini, GP, Valenzuela, DM, West, AP & Wurst, W 2016, 'Genome wide conditional mouse knockout resources' Drug Discovery Today: Disease Models, vol. 20, pp. 3-12. https://doi.org/10.1016/j.ddmod.2017.08.002

Genome wide conditional mouse knockout resources. / Kaloff, C.; Anastassiadis, Konstantinos; Ayadi, A.; Baldock, R; Beig, J.; Birling, M. C.; Bradley, A.; Brown, S. D.M.; Bürger, A.; Bushell, W.; Chiani, Francesco; Collins, F. S.; Doe, Brendan; Eppig, J. T.; Finnell, R. H.; Fletcher, Jennifer C; Flicek, Paul; El Fray, Mirca; Friedel, R. H.; Gambadoro, A.; Gates, Hilary; Hansen, J.; Herault, Y.; Hicks, Gemma; Hörlein, A.; Hrabé de Angelis, M.; Iyer, V. J.; de Jong, P. J.; Koscielny, G.; Kühn, R.; Liu, P.; Lloyd, K. C.K.; Lopez, R. G.; Marschall, Jeffrey S.; Martínez, S.; McKerlie, C.; Meehan, T.; von Melchner, H.; Moore, M.; Murray, S. A.; Nagy, A.; Nutter, L. M.J.; Pavlovic, G.; Pombero, A.; Prosser, H.; Ramirez-Solis, Ramiro; Ringwald, Martin; Rosen, Barry; Rosenthal, N.; Rossant, Janet; Ruiz Noppinger, P.; Ryder, Ed; Skarnes, William C; Schick, J.; Schnütgen, F.; Schofield, P E; Seisenberger, C.; Selloum, M.; Smedley, Damian P; Simpson, E. M.; Stewart, A. F.; Teboul, Lydia; Tocchini Valentini, G. P.; Valenzuela, David M; West, A. P.; Wurst, W.

In: Drug Discovery Today: Disease Models, Vol. 20, 2016, p. 3-12.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Genome wide conditional mouse knockout resources

AU - Kaloff, C.

AU - Anastassiadis, Konstantinos

AU - Ayadi, A.

AU - Baldock, R

AU - Beig, J.

AU - Birling, M. C.

AU - Bradley, A.

AU - Brown, S. D.M.

AU - Bürger, A.

AU - Bushell, W.

AU - Chiani, Francesco

AU - Collins, F. S.

AU - Doe, Brendan

AU - Eppig, J. T.

AU - Finnell, R. H.

AU - Fletcher, Jennifer C

AU - Flicek, Paul

AU - El Fray, Mirca

AU - Friedel, R. H.

AU - Gambadoro, A.

AU - Gates, Hilary

AU - Hansen, J.

AU - Herault, Y.

AU - Hicks, Gemma

AU - Hörlein, A.

AU - Hrabé de Angelis, M.

AU - Iyer, V. J.

AU - de Jong, P. J.

AU - Koscielny, G.

AU - Kühn, R.

AU - Liu, P.

AU - Lloyd, K. C.K.

AU - Lopez, R. G.

AU - Marschall, Jeffrey S.

AU - Martínez, S.

AU - McKerlie, C.

AU - Meehan, T.

AU - von Melchner, H.

AU - Moore, M.

AU - Murray, S. A.

AU - Nagy, A.

AU - Nutter, L. M.J.

AU - Pavlovic, G.

AU - Pombero, A.

AU - Prosser, H.

AU - Ramirez-Solis, Ramiro

AU - Ringwald, Martin

AU - Rosen, Barry

AU - Rosenthal, N.

AU - Rossant, Janet

AU - Ruiz Noppinger, P.

AU - Ryder, Ed

AU - Skarnes, William C

AU - Schick, J.

AU - Schnütgen, F.

AU - Schofield, P E

AU - Seisenberger, C.

AU - Selloum, M.

AU - Smedley, Damian P

AU - Simpson, E. M.

AU - Stewart, A. F.

AU - Teboul, Lydia

AU - Tocchini Valentini, G. P.

AU - Valenzuela, David M

AU - West, A. P.

AU - Wurst, W

PY - 2016

Y1 - 2016

N2 - The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

AB - The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

UR - http://www.scopus.com/inward/record.url?scp=85029227398&partnerID=8YFLogxK

U2 - 10.1016/j.ddmod.2017.08.002

DO - 10.1016/j.ddmod.2017.08.002

M3 - Article

VL - 20

SP - 3

EP - 12

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

SN - 1740-6757

ER -

Kaloff C, Anastassiadis K, Ayadi A, Baldock R, Beig J, Birling MC et al. Genome wide conditional mouse knockout resources. Drug Discovery Today: Disease Models. 2016;20:3-12. https://doi.org/10.1016/j.ddmod.2017.08.002