Projects per year
Abstract
Intra-individual response time variability (IIRTV) is proposed as a viable endophenotype for many psychiatric disorders, particularly attention-deficit hyperactivity disorder (ADHD). Here we assessed whether IIRTV was associated with common DNA variation genome-wide and whether IIRTV mediated the relationship between any associated loci and self-reported ADHD symptoms. A final data set from 857 Australian young adults (489 females and 368 males; Mage = 22.14 years, SDage = 4.82 years) who completed five response time tasks and self-reported symptoms of ADHD using the Conners’ Adult ADHD Rating Scale was used. Principal components analysis (PCA) on these response time measures (standard deviation of reaction times and the intra-individual coefficient of variation) produced two variability factors (labelled response selection and selective attention). To understand the genetic drivers of IIRTV we performed a genome-wide association analysis (GWAS) on these PCA-derived indices of IIRTV. For the selective attention variability factor, we identified one single-nucleotide polymorphism (SNP) attaining genome-wide significance; rs62182100 in the HDAC4 gene located on chromosome 2q37. A bootstrapping mediation analysis demonstrated that the selective attention variability factor mediated the relationship between rs62182100 and self-reported ADHD symptoms. Our findings provide the first evidence of a genome-wide significant SNP association with IIRTV and support the potential utility of IIRTV as a valid endophenotype for ADHD symptoms. However, limitations of this study suggest that these observations should be interpreted with caution until replication samples become available.
Original language | English |
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Article number | 207 |
Number of pages | 8 |
Journal | Translational Psychiatry |
Volume | 8 |
Issue number | 1 |
DOIs | |
Publication status | Published - 4 Oct 2018 |
Keywords
- biomarkers
- genomics
Projects
- 4 Finished
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Cognitive neuroscience of spatial asymmetry: behaviour, genes and brain imaging
Australian Research Council (ARC)
2/01/14 → 31/12/17
Project: Research
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The genetics of ADHD: role of rare variants
Bellgrove, M. (Primary Chief Investigator (PCI)), Hawi, Z. (Chief Investigator (CI)), Arcos-Burgos, M. (Chief Investigator (CI)), Easteal, S. (Chief Investigator (CI)), Vance, A. L. A. (Chief Investigator (CI)), Levy, F. (Chief Investigator (CI)) & Cummins, T. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/16
Project: Research
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Cognitive Neuroscience of Error Processing
Bellgrove, M. (Primary Chief Investigator (PCI)), Cummins, T. (Chief Investigator (CI)), Garavan, H. (Chief Investigator (CI)) & Hester, R. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/15
Project: Research
Activities
- 1 Professional association or peak discipline body
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Australasian ADHD Professionals Association (AADPA) Curent Member
Tiego, J. (Member)
18 Sept 2024Activity: External Academic Engagement › Professional association or peak discipline body