TY - JOUR
T1 - Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
AU - Sud, Amit
AU - Thomsen, Hauke
AU - Law, Philip J.
AU - Försti, Asta
AU - Filho, Miguel Inacio Da Silva
AU - Holroyd, Amy
AU - Broderick, Peter
AU - Orlando, Giulia
AU - Lenive, Oleg
AU - Wright, Lauren
AU - Cooke, Rosie
AU - Easton, Douglas
AU - Pharoah, Paul
AU - Dunning, Alison
AU - Peto, Julian
AU - Canzian, Federico
AU - Eeles, Rosalind
AU - Kote-Jarai, ZSofia
AU - Muir, Kenneth
AU - Pashayan, Nora
AU - Henderson, Brian E.
AU - Haiman, Christopher A.
AU - Benlloch, Sara
AU - Schumacher, Fredrick R.
AU - Olama, Ali Amin Al
AU - Berndt, Sonja I.
AU - Conti, David V.
AU - Wiklund, Fredrik
AU - Chanock, Stephen
AU - Stevens, Victoria L.
AU - Tangen, Catherine M.
AU - Batra, Jyotsna
AU - Clements, Judith
AU - Gronberg, Henrik
AU - Schleutker, Johanna
AU - Albanes, Demetrius
AU - Weinstein, Stephanie
AU - Wolk, Alicja
AU - West, Catharine
AU - Mucci, Lorelei
AU - Cancel-Tassin, Géraldine
AU - Koutros, Stella
AU - Sorensen, Karina Dalsgaard
AU - Maehle, Lovise
AU - Neal, David E.
AU - Travis, Ruth C.
AU - Hamilton, Robert J.
AU - Ingles, Sue Ann
AU - Rosenstein, Barry
AU - Lu, Yong Jie
AU - Giles, Graham G.
AU - Kibel, Adam S.
AU - Vega, Ana
AU - Kogevinas, Manolis
AU - Penney, Kathryn L.
AU - Park, Jong Y.
AU - Stanford, Janet L.
AU - Cybulski, Cezary
AU - Nordestgaard, Børge G.
AU - Brenner, Hermann
AU - Maier, Christiane
AU - Kim, Jeri
AU - John, Esther M.
AU - Teixeira, Manuel R.
AU - Neuhausen, Susan L.
AU - De Ruyck, Kim
AU - Razack, Azad
AU - Newcomb, Lisa F.
AU - Lessel, Davor
AU - Kaneva, Radka
AU - Usmani, Nawaid
AU - Claessens, Frank
AU - Townsend, Paul A.
AU - Dominguez, Manuela Gago
AU - Roobol, Monique J.
AU - Menegaux, Florence
AU - Hoffmann, Per
AU - The PRACTICAL consortium
AU - Nöthen, Markus M.
AU - Jöckel, Karl Heinz
AU - Strandmann, Elke Pogge Von
AU - Lightfoot, Tracy
AU - Kane, Eleanor
AU - Roman, Eve
AU - Lake, Annette
AU - Montgomery, Dorothy
AU - Jarrett, Ruth F.
AU - Swerdlow, Anthony J.
AU - Engert, Andreas
AU - Orr, Nick
AU - Hemminki, Kari
AU - Houlston, Richard S.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1 03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
AB - Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1 03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
UR - http://www.scopus.com/inward/record.url?scp=85036669716&partnerID=8YFLogxK
U2 - 10.1038/s41467-017-00320-1
DO - 10.1038/s41467-017-00320-1
M3 - Article
C2 - 29196614
AN - SCOPUS:85036669716
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 1892
ER -