Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Brian M. Wolpin; Cosmeri Rizzato; Peter Kraft; Charles Kooperberg; Gloria M Petersen; Zhaoming Wang; Alan A. Arslan; Laura Beane-Freeman; Paige M. Bracci; Julie E Buring; Federico Canzian; Eric J. Duell; Steven Gallinger; Graham G. Giles; Gary E. Goodman; Phyllis J. Goodman; Eric J. Jacobs; Aruna Kamineni; Alison P Klein; Laurence N Kolonel

doi:10.1038/ng.3052

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Brian M. Wolpin
, Cosmeri Rizzato
, Peter Kraft
, Charles Kooperberg
, Gloria M Petersen
, Zhaoming Wang
, Alan A. Arslan
, Laura Beane-Freeman
, Paige M. Bracci
, Julie E Buring
, Federico Canzian
, Eric J. Duell
, Steven Gallinger
, Graham G. Giles
, Gary E. Goodman
, Phyllis J. Goodman
, Eric J. Jacobs
, Aruna Kamineni
, Alison P Klein
, Laurence N Kolonel

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

295 Citations (Scopus)

Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10^-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10^-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10^-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10^-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10^-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10^-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Original language	English
Pages (from-to)	994-1000
Number of pages	7
Journal	Nature Genetics
Volume	46
Issue number	9
DOIs	https://doi.org/10.1038/ng.3052
Publication status	Published - 2014

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Wolpin, B. M., Rizzato, C., Kraft, P., Kooperberg, C., Petersen, G. M., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Buring, J. E., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goodman, G. E., Goodman, P. J., Jacobs, E. J., Kamineni, A., Klein, A. P., & Kolonel, L. N. (2014). Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nature Genetics, 46(9), 994-1000. https://doi.org/10.1038/ng.3052

@article{413a6bce886743cca5d50625484194bb,

title = "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer",

abstract = "We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95\% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95\% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95\% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95\% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95\% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.",

author = "Wolpin, \{Brian M.\} and Cosmeri Rizzato and Peter Kraft and Charles Kooperberg and Petersen, \{Gloria M\} and Zhaoming Wang and Arslan, \{Alan A.\} and Laura Beane-Freeman and Bracci, \{Paige M.\} and Buring, \{Julie E\} and Federico Canzian and Duell, \{Eric J.\} and Steven Gallinger and Giles, \{Graham G.\} and Goodman, \{Gary E.\} and Goodman, \{Phyllis J.\} and Jacobs, \{Eric J.\} and Aruna Kamineni and Klein, \{Alison P\} and Kolonel, \{Laurence N\}",

year = "2014",

doi = "10.1038/ng.3052",

language = "English",

volume = "46",

pages = "994--1000",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "9",

}

Wolpin, BM, Rizzato, C, Kraft, P, Kooperberg, C, Petersen, GM, Wang, Z, Arslan, AA, Beane-Freeman, L, Bracci, PM, Buring, JE, Canzian, F, Duell, EJ, Gallinger, S, Giles, GG, Goodman, GE, Goodman, PJ, Jacobs, EJ, Kamineni, A, Klein, AP & Kolonel, LN 2014, 'Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer', Nature Genetics, vol. 46, no. 9, pp. 994-1000. https://doi.org/10.1038/ng.3052

TY - JOUR

T1 - Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

AU - Wolpin, Brian M.

AU - Rizzato, Cosmeri

AU - Kraft, Peter

AU - Kooperberg, Charles

AU - Petersen, Gloria M

AU - Wang, Zhaoming

AU - Arslan, Alan A.

AU - Beane-Freeman, Laura

AU - Bracci, Paige M.

AU - Buring, Julie E

AU - Canzian, Federico

AU - Duell, Eric J.

AU - Gallinger, Steven

AU - Giles, Graham G.

AU - Goodman, Gary E.

AU - Goodman, Phyllis J.

AU - Jacobs, Eric J.

AU - Kamineni, Aruna

AU - Klein, Alison P

AU - Kolonel, Laurence N

PY - 2014

Y1 - 2014

N2 - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

AB - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

UR - https://www.scopus.com/pages/publications/84938423709

U2 - 10.1038/ng.3052

DO - 10.1038/ng.3052

M3 - Article

C2 - 25086665

AN - SCOPUS:84938423709

SN - 1061-4036

VL - 46

SP - 994

EP - 1000

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Abstract

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