TY - JOUR
T1 - Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
AU - Wolpin, Brian M.
AU - Rizzato, Cosmeri
AU - Kraft, Peter
AU - Kooperberg, Charles
AU - Petersen, Gloria M
AU - Wang, Zhaoming
AU - Arslan, Alan A.
AU - Beane-Freeman, Laura
AU - Bracci, Paige M.
AU - Buring, Julie E
AU - Canzian, Federico
AU - Duell, Eric J.
AU - Gallinger, Steven
AU - Giles, Graham G.
AU - Goodman, Gary E.
AU - Goodman, Phyllis J.
AU - Jacobs, Eric J.
AU - Kamineni, Aruna
AU - Klein, Alison P
AU - Kolonel, Laurence N
PY - 2014
Y1 - 2014
N2 - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
AB - We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
UR - http://www.scopus.com/inward/record.url?scp=84938423709&partnerID=8YFLogxK
U2 - 10.1038/ng.3052
DO - 10.1038/ng.3052
M3 - Article
C2 - 25086665
AN - SCOPUS:84938423709
SN - 1061-4036
VL - 46
SP - 994
EP - 1000
JO - Nature Genetics
JF - Nature Genetics
IS - 9
ER -