Abstract
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
Original language | English |
---|---|
Pages (from-to) | 1142-1146 |
Number of pages | 5 |
Journal | Nature Genetics |
Volume | 44 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 2012 |
Externally published | Yes |
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Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. / Vithana, Eranga N.; Khor, Chiea Chuen; Qiao, Chunyan; Nongpiur, Monisha E.; George, Ronnie; Chen, Li Jia; Do, Tan; Abu-Amero, Khaled K; Huang, Chor Kai; Low, Sancy; Tajudin, Liza Sharmini A.; Perera, Shamira A.; Cheng, Ching-Yu; Xu, Liang; Jia, Hongyan; Ho, Ching Lin; Sim, Kar Seng; Wu, Ren Yi; Tham, Clement C.Y.; Chew, Paul T.K.; Su, Daniel H.; Oen, Francis T.; Sarangapani, Sripriya; Soumittra, Nagaswamy; Osman, Essam A.; Wong, Hon Tym; Tang, Guangxian; Fan, Sujie; Meng, Hailin; Huong, Dao T.L.; Wang, Wei-Hua; Feng, Bo; Baskaran, Mani; Shantha, Balekudaru; Ramprasad, Vedam L.; Kumaramanickavel, Govindasamy; Iyengar, Sudha K.; How, Alicia C.; Lee, Kelvin Y.; Sivakumaran, Theru A.; Yong, Victor H.K.; Ting, Serena M.L.; Li, Yang; Wang, Ya Xing; Tay, Wan Ting; Sim, Xueling; Lavanya, Raghavan; Cornes, Belinda K.; Zheng, Ying Feng; Wong, Tina T.; Loon, Seng Chee; Yong, Vernon K.Y.; Waseem, Naushin; Yaakub, Azhany; Chia, Kee Seng; Rand Allingham, R.; Hauser, Michael A.; Lam, Dennis Shun Chiu; Hibberd, Martin L.; Bhattacharya, Shomi S; Zhang, Mingzhi; Teo, Yik-Ying; Tan, Donald T.; Jonas, Jost B; Tai, E. Shyong; Saw, Seang Mei; Hon, Do Nhu; Al-Obeidan, Saleh A.; Liu, Jianjun; Chau, Tran Nguyen Bich; Simmons, Cameron P.; Bei, Jin Xin; Zeng, Yi Xin; Foster, Paul J.; Vijaya, Lingam; Wong, Tien Yin; Pang, Chi Pui; Wang, Ningli; Aung, Tin.
In: Nature Genetics, Vol. 44, No. 10, 10.2012, p. 1142-1146.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
AU - Vithana, Eranga N.
AU - Khor, Chiea Chuen
AU - Qiao, Chunyan
AU - Nongpiur, Monisha E.
AU - George, Ronnie
AU - Chen, Li Jia
AU - Do, Tan
AU - Abu-Amero, Khaled K
AU - Huang, Chor Kai
AU - Low, Sancy
AU - Tajudin, Liza Sharmini A.
AU - Perera, Shamira A.
AU - Cheng, Ching-Yu
AU - Xu, Liang
AU - Jia, Hongyan
AU - Ho, Ching Lin
AU - Sim, Kar Seng
AU - Wu, Ren Yi
AU - Tham, Clement C.Y.
AU - Chew, Paul T.K.
AU - Su, Daniel H.
AU - Oen, Francis T.
AU - Sarangapani, Sripriya
AU - Soumittra, Nagaswamy
AU - Osman, Essam A.
AU - Wong, Hon Tym
AU - Tang, Guangxian
AU - Fan, Sujie
AU - Meng, Hailin
AU - Huong, Dao T.L.
AU - Wang, Wei-Hua
AU - Feng, Bo
AU - Baskaran, Mani
AU - Shantha, Balekudaru
AU - Ramprasad, Vedam L.
AU - Kumaramanickavel, Govindasamy
AU - Iyengar, Sudha K.
AU - How, Alicia C.
AU - Lee, Kelvin Y.
AU - Sivakumaran, Theru A.
AU - Yong, Victor H.K.
AU - Ting, Serena M.L.
AU - Li, Yang
AU - Wang, Ya Xing
AU - Tay, Wan Ting
AU - Sim, Xueling
AU - Lavanya, Raghavan
AU - Cornes, Belinda K.
AU - Zheng, Ying Feng
AU - Wong, Tina T.
AU - Loon, Seng Chee
AU - Yong, Vernon K.Y.
AU - Waseem, Naushin
AU - Yaakub, Azhany
AU - Chia, Kee Seng
AU - Rand Allingham, R.
AU - Hauser, Michael A.
AU - Lam, Dennis Shun Chiu
AU - Hibberd, Martin L.
AU - Bhattacharya, Shomi S
AU - Zhang, Mingzhi
AU - Teo, Yik-Ying
AU - Tan, Donald T.
AU - Jonas, Jost B
AU - Tai, E. Shyong
AU - Saw, Seang Mei
AU - Hon, Do Nhu
AU - Al-Obeidan, Saleh A.
AU - Liu, Jianjun
AU - Chau, Tran Nguyen Bich
AU - Simmons, Cameron P.
AU - Bei, Jin Xin
AU - Zeng, Yi Xin
AU - Foster, Paul J.
AU - Vijaya, Lingam
AU - Wong, Tien Yin
AU - Pang, Chi Pui
AU - Wang, Ningli
AU - Aung, Tin
PY - 2012/10
Y1 - 2012/10
N2 - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
AB - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.
UR - http://www.scopus.com/inward/record.url?scp=84866888701&partnerID=8YFLogxK
U2 - 10.1038/ng.2390
DO - 10.1038/ng.2390
M3 - Article
AN - SCOPUS:84866888701
VL - 44
SP - 1142
EP - 1146
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -