Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Eranga N. Vithana; Chiea Chuen Khor; Chunyan Qiao; Monisha E. Nongpiur; Ronnie George; Li Jia Chen; Tan Do; Khaled K Abu-Amero; Chor Kai Huang; Sancy Low; Liza Sharmini A. Tajudin; Shamira A. Perera; Ching-Yu Cheng; Liang Xu; Hongyan Jia; Ching Lin Ho; Kar Seng Sim; Ren Yi Wu; Clement C.Y. Tham; Paul T.K. Chew; Daniel H. Su; Francis T. Oen; Sripriya Sarangapani; Nagaswamy Soumittra; Essam A. Osman; Hon Tym Wong; Guangxian Tang; Sujie Fan; Hailin Meng; Dao T.L. Huong; Wei-Hua Wang; Bo Feng; Mani Baskaran; Balekudaru Shantha; Vedam L. Ramprasad; Govindasamy Kumaramanickavel; Sudha K. Iyengar; Alicia C. How; Kelvin Y. Lee; Theru A. Sivakumaran; Victor H.K. Yong; Serena M.L. Ting; Yang Li; Ya Xing Wang; Wan Ting Tay; Xueling Sim; Raghavan Lavanya; Belinda K. Cornes; Ying Feng Zheng; Tina T. Wong; Seng Chee Loon; Vernon K.Y. Yong; Naushin Waseem; Azhany Yaakub; Kee Seng Chia; R. Rand Allingham; Michael A. Hauser; Dennis Shun Chiu Lam; Martin L. Hibberd; Shomi S Bhattacharya; Mingzhi Zhang; Yik-Ying Teo; Donald T. Tan; Jost B Jonas; E. Shyong Tai; Seang Mei Saw; Do Nhu Hon; Saleh A. Al-Obeidan; Jianjun Liu; Tran Nguyen Bich Chau; Cameron P. Simmons; Jin Xin Bei; Yi Xin Zeng; Paul J. Foster; Lingam Vijaya; Tien Yin Wong; Chi Pui Pang; Ningli Wang; Tin Aung

doi:10.1038/ng.2390

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Eranga N. Vithana, Chiea Chuen Khor, Chunyan Qiao, Monisha E. Nongpiur, Ronnie George, Li Jia Chen, Tan Do, Khaled K Abu-Amero, Chor Kai Huang, Sancy Low, Liza Sharmini A. Tajudin, Shamira A. Perera, Ching-Yu Cheng, Liang Xu, Hongyan Jia, Ching Lin Ho, Kar Seng Sim, Ren Yi Wu, Clement C.Y. Tham, Paul T.K. ChewDaniel H. Su, Francis T. Oen, Sripriya Sarangapani, Nagaswamy Soumittra, Essam A. Osman, Hon Tym Wong, Guangxian Tang, Sujie Fan, Hailin Meng, Dao T.L. Huong, Wei-Hua Wang, Bo Feng, Mani Baskaran, Balekudaru Shantha, Vedam L. Ramprasad, Govindasamy Kumaramanickavel, Sudha K. Iyengar, Alicia C. How, Kelvin Y. Lee, Theru A. Sivakumaran, Victor H.K. Yong, Serena M.L. Ting, Yang Li, Ya Xing Wang, Wan Ting Tay, Xueling Sim, Raghavan Lavanya, Belinda K. Cornes, Ying Feng Zheng, Tina T. Wong, Seng Chee Loon, Vernon K.Y. Yong, Naushin Waseem, Azhany Yaakub, Kee Seng Chia, R. Rand Allingham, Michael A. Hauser, Dennis Shun Chiu Lam, Martin L. Hibberd, Shomi S Bhattacharya, Mingzhi Zhang, Yik-Ying Teo, Donald T. Tan, Jost B Jonas, E. Shyong Tai, Seang Mei Saw, Do Nhu Hon, Saleh A. Al-Obeidan, Jianjun Liu, Tran Nguyen Bich Chau, Cameron P. Simmons, Jin Xin Bei, Yi Xin Zeng, Paul J. Foster, Lingam Vijaya, Tien Yin Wong, Chi Pui Pang, Ningli Wang, Tin Aung

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Abstract

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10^-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10^-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10^-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.

Original language	English
Pages (from-to)	1142-1146
Number of pages	5
Journal	Nature Genetics
Volume	44
Issue number	10
DOIs	https://doi.org/10.1038/ng.2390
Publication status	Published - Oct 2012
Externally published	Yes

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Vithana, E. N., Khor, C. C., Qiao, C., Nongpiur, M. E., George, R., Chen, L. J., Do, T., Abu-Amero, K. K., Huang, C. K., Low, S., Tajudin, L. S. A., Perera, S. A., Cheng, C.-Y., Xu, L., Jia, H., Ho, C. L., Sim, K. S., Wu, R. Y., Tham, C. C. Y., ... Aung, T. (2012). Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nature Genetics, 44(10), 1142-1146. https://doi.org/10.1038/ng.2390

@article{317e2d0f9fe14af2b66f05e5eca2313b,

title = "Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma",

abstract = "Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.",

author = "Vithana, {Eranga N.} and Khor, {Chiea Chuen} and Chunyan Qiao and Nongpiur, {Monisha E.} and Ronnie George and Chen, {Li Jia} and Tan Do and Abu-Amero, {Khaled K} and Huang, {Chor Kai} and Sancy Low and Tajudin, {Liza Sharmini A.} and Perera, {Shamira A.} and Ching-Yu Cheng and Liang Xu and Hongyan Jia and Ho, {Ching Lin} and Sim, {Kar Seng} and Wu, {Ren Yi} and Tham, {Clement C.Y.} and Chew, {Paul T.K.} and Su, {Daniel H.} and Oen, {Francis T.} and Sripriya Sarangapani and Nagaswamy Soumittra and Osman, {Essam A.} and Wong, {Hon Tym} and Guangxian Tang and Sujie Fan and Hailin Meng and Huong, {Dao T.L.} and Wei-Hua Wang and Bo Feng and Mani Baskaran and Balekudaru Shantha and Ramprasad, {Vedam L.} and Govindasamy Kumaramanickavel and Iyengar, {Sudha K.} and How, {Alicia C.} and Lee, {Kelvin Y.} and Sivakumaran, {Theru A.} and Yong, {Victor H.K.} and Ting, {Serena M.L.} and Yang Li and Wang, {Ya Xing} and Tay, {Wan Ting} and Xueling Sim and Raghavan Lavanya and Cornes, {Belinda K.} and Zheng, {Ying Feng} and Wong, {Tina T.} and Loon, {Seng Chee} and Yong, {Vernon K.Y.} and Naushin Waseem and Azhany Yaakub and Chia, {Kee Seng} and {Rand Allingham}, R. and Hauser, {Michael A.} and Lam, {Dennis Shun Chiu} and Hibberd, {Martin L.} and Bhattacharya, {Shomi S} and Mingzhi Zhang and Yik-Ying Teo and Tan, {Donald T.} and Jonas, {Jost B} and Tai, {E. Shyong} and Saw, {Seang Mei} and Hon, {Do Nhu} and Al-Obeidan, {Saleh A.} and Jianjun Liu and Chau, {Tran Nguyen Bich} and Simmons, {Cameron P.} and Bei, {Jin Xin} and Zeng, {Yi Xin} and Foster, {Paul J.} and Lingam Vijaya and Wong, {Tien Yin} and Pang, {Chi Pui} and Ningli Wang and Tin Aung",

year = "2012",

month = oct,

doi = "10.1038/ng.2390",

language = "English",

volume = "44",

pages = "1142--1146",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "10",

}

Vithana, EN, Khor, CC, Qiao, C, Nongpiur, ME, George, R, Chen, LJ, Do, T, Abu-Amero, KK, Huang, CK, Low, S, Tajudin, LSA, Perera, SA, Cheng, C-Y, Xu, L, Jia, H, Ho, CL, Sim, KS, Wu, RY, Tham, CCY, Chew, PTK, Su, DH, Oen, FT, Sarangapani, S, Soumittra, N, Osman, EA, Wong, HT, Tang, G, Fan, S, Meng, H, Huong, DTL, Wang, W-H, Feng, B, Baskaran, M, Shantha, B, Ramprasad, VL, Kumaramanickavel, G, Iyengar, SK, How, AC, Lee, KY, Sivakumaran, TA, Yong, VHK, Ting, SML, Li, Y, Wang, YX, Tay, WT, Sim, X, Lavanya, R, Cornes, BK, Zheng, YF, Wong, TT, Loon, SC, Yong, VKY, Waseem, N, Yaakub, A, Chia, KS, Rand Allingham, R, Hauser, MA, Lam, DSC, Hibberd, ML, Bhattacharya, SS, Zhang, M, Teo, Y-Y, Tan, DT, Jonas, JB, Tai, ES, Saw, SM, Hon, DN, Al-Obeidan, SA, Liu, J, Chau, TNB, Simmons, CP, Bei, JX, Zeng, YX, Foster, PJ, Vijaya, L, Wong, TY, Pang, CP, Wang, N & Aung, T 2012, 'Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma', Nature Genetics, vol. 44, no. 10, pp. 1142-1146. https://doi.org/10.1038/ng.2390

TY - JOUR

T1 - Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

AU - Vithana, Eranga N.

AU - Khor, Chiea Chuen

AU - Qiao, Chunyan

AU - Nongpiur, Monisha E.

AU - George, Ronnie

AU - Chen, Li Jia

AU - Do, Tan

AU - Abu-Amero, Khaled K

AU - Huang, Chor Kai

AU - Low, Sancy

AU - Tajudin, Liza Sharmini A.

AU - Perera, Shamira A.

AU - Cheng, Ching-Yu

AU - Xu, Liang

AU - Jia, Hongyan

AU - Ho, Ching Lin

AU - Sim, Kar Seng

AU - Wu, Ren Yi

AU - Tham, Clement C.Y.

AU - Chew, Paul T.K.

AU - Su, Daniel H.

AU - Oen, Francis T.

AU - Sarangapani, Sripriya

AU - Soumittra, Nagaswamy

AU - Osman, Essam A.

AU - Wong, Hon Tym

AU - Tang, Guangxian

AU - Fan, Sujie

AU - Meng, Hailin

AU - Huong, Dao T.L.

AU - Wang, Wei-Hua

AU - Feng, Bo

AU - Baskaran, Mani

AU - Shantha, Balekudaru

AU - Ramprasad, Vedam L.

AU - Kumaramanickavel, Govindasamy

AU - Iyengar, Sudha K.

AU - How, Alicia C.

AU - Lee, Kelvin Y.

AU - Sivakumaran, Theru A.

AU - Yong, Victor H.K.

AU - Ting, Serena M.L.

AU - Li, Yang

AU - Wang, Ya Xing

AU - Tay, Wan Ting

AU - Sim, Xueling

AU - Lavanya, Raghavan

AU - Cornes, Belinda K.

AU - Zheng, Ying Feng

AU - Wong, Tina T.

AU - Loon, Seng Chee

AU - Yong, Vernon K.Y.

AU - Waseem, Naushin

AU - Yaakub, Azhany

AU - Chia, Kee Seng

AU - Rand Allingham, R.

AU - Hauser, Michael A.

AU - Lam, Dennis Shun Chiu

AU - Hibberd, Martin L.

AU - Bhattacharya, Shomi S

AU - Zhang, Mingzhi

AU - Teo, Yik-Ying

AU - Tan, Donald T.

AU - Jonas, Jost B

AU - Tai, E. Shyong

AU - Saw, Seang Mei

AU - Hon, Do Nhu

AU - Al-Obeidan, Saleh A.

AU - Liu, Jianjun

AU - Chau, Tran Nguyen Bich

AU - Simmons, Cameron P.

AU - Bei, Jin Xin

AU - Zeng, Yi Xin

AU - Foster, Paul J.

AU - Vijaya, Lingam

AU - Wong, Tien Yin

AU - Pang, Chi Pui

AU - Wang, Ningli

AU - Aung, Tin

PY - 2012/10

Y1 - 2012/10

N2 - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.

AB - Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.

UR - http://www.scopus.com/inward/record.url?scp=84866888701&partnerID=8YFLogxK

U2 - 10.1038/ng.2390

DO - 10.1038/ng.2390

M3 - Article

AN - SCOPUS:84866888701

SN - 1061-4036

VL - 44

SP - 1142

EP - 1146

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

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