TY - JOUR
T1 - Genome-wide analysis provides a deeper understanding of the population structure of the Salmonella enterica serotype Paratyphi B complex in Bangladesh
AU - Rahman, Sadia Isfat Ara
AU - Taylor-Brown, Alyce
AU - Khanam, Farhana
AU - Khan, Ashraful Islam
AU - Horesh, Gal
AU - Dyson, Zoe A.
AU - Begum, Yasmin Ara
AU - Chowdhury, Emran Kabir
AU - Qadri, Firdausi
AU - Dougan, Gordon
AU - Thomson, Nicholas R.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/9/1
Y1 - 2021/9/1
N2 - The Salmonella enterica serotype Paratyphi B complex causes a wide range of diseases, from gastroenteritis to paratyphoid fever, depending on the biotypes Java and sensu stricto. The burden of Paratyphi B biotypes in Bangladesh is still unknown, as these are indistinguishable by Salmonella serotyping. Here, we conducted the first whole-genome sequencing (WGS) study on 79 Salmonella isolates serotyped as Paratyphi B that were collected from 10 nationwide enteric disease surveillance sites in Bangladesh. Placing these in a global genetic context revealed that these are biotype Java, and the addition of these genomes expanded the previously described PG4 clade containing Bangladeshi and UK isolates. Importantly, antimicrobial resistance (AMR) genes were scarce amongst Bangladeshi S. Java isolates, somewhat surprisingly given the widespread availability of antibiotics without prescription. This genomic information provides important insights into the significance of S. Paratyphi B biotypes in enteric disease and their implications for public health.
AB - The Salmonella enterica serotype Paratyphi B complex causes a wide range of diseases, from gastroenteritis to paratyphoid fever, depending on the biotypes Java and sensu stricto. The burden of Paratyphi B biotypes in Bangladesh is still unknown, as these are indistinguishable by Salmonella serotyping. Here, we conducted the first whole-genome sequencing (WGS) study on 79 Salmonella isolates serotyped as Paratyphi B that were collected from 10 nationwide enteric disease surveillance sites in Bangladesh. Placing these in a global genetic context revealed that these are biotype Java, and the addition of these genomes expanded the previously described PG4 clade containing Bangladeshi and UK isolates. Importantly, antimicrobial resistance (AMR) genes were scarce amongst Bangladeshi S. Java isolates, somewhat surprisingly given the widespread availability of antibiotics without prescription. This genomic information provides important insights into the significance of S. Paratyphi B biotypes in enteric disease and their implications for public health.
KW - enteric disease
KW - Salmonella Paratyphi B
KW - serotyping
KW - surveillance
KW - whole-genome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85116761680&partnerID=8YFLogxK
U2 - 10.1099/mgen.0.000617
DO - 10.1099/mgen.0.000617
M3 - Article
C2 - 34550065
AN - SCOPUS:85116761680
SN - 2057-5858
VL - 7
JO - Microbial Genomics
JF - Microbial Genomics
IS - 9
ER -