Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution

Kim Tien Ng, Yutaka Takebe, Adeeba Kamarulzaman, Kok Keng Tee

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3 Citations (Scopus)


Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique “clade-defining” substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5ʹ-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalArchives of Virology
Issue number1
Publication statusPublished - Jan 2021
Externally publishedYes

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