TY - JOUR
T1 - Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide distribution
AU - Ng, Kim Tien
AU - Takebe, Yutaka
AU - Kamarulzaman, Adeeba
AU - Tee, Kok Keng
N1 - Funding Information:
This work was supported in part by grants from the Ministry of Higher Education, Malaysia: High Impact Research UM.C/625/1/HIR/MOE/CHAN/02/02 to K.K.T and Postgraduate Research Fund (PG097-2015A) to K.T.N. We would like to thank Ann C. Palmenberg (University of Wisconsin) for discussion and advice.
Publisher Copyright:
© 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2021/1
Y1 - 2021/1
N2 - Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique “clade-defining” substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5ʹ-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
AB - Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique “clade-defining” substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5ʹ-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
UR - http://www.scopus.com/inward/record.url?scp=85093072366&partnerID=8YFLogxK
U2 - 10.1007/s00705-020-04855-5
DO - 10.1007/s00705-020-04855-5
M3 - Article
C2 - 33084935
AN - SCOPUS:85093072366
SN - 0304-8608
VL - 166
SP - 225
EP - 229
JO - Archives of Virology
JF - Archives of Virology
IS - 1
ER -