Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia

Kim Tien Ng; Lai Yee Ong; Yutaka Takebe; Adeeba Kamarulzaman; Kok Keng Tee

doi:10.1128/JVI.01949-12

Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia

Kim Tien Ng
, Lai Yee Ong
, Yutaka Takebe
, Adeeba Kamarulzaman
, Kok Keng Tee

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B= and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B= and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

Original language	English
Pages (from-to)	11405-11406
Number of pages	2
Journal	Journal of Virology
Volume	86
Issue number	20
DOIs	https://doi.org/10.1128/JVI.01949-12
Publication status	Published - Oct 2012
Externally published	Yes

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abstract = "We report here the first novel HIV-1 circulating recombinant form (CRF) 54\_01B (CRF54\_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B= and CRF01\_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B= and CRF01\_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.",

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AU - Ng, Kim Tien

AU - Ong, Lai Yee

AU - Takebe, Yutaka

AU - Kamarulzaman, Adeeba

AU - Tee, Kok Keng

PY - 2012/10

Y1 - 2012/10

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AB - We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B= and CRF01_AE, with identical recombination breakpoints observed in the gag, pol, and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B= and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

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JF - Journal of Virology

IS - 20

ER -

Genome sequence of a novel HIV-1 circulating recombinant form 54_01B from Malaysia

Abstract

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