Genome sequence analysis of a hypermucoviscous/hypervirulent and MDR CTX-M-15/K19/ST29 Klebsiella pneumoniae isolated from human infection

Quézia Moura, Fernanda Esposito, Miriam R. Fernandes, Maria Espinoza-Muñoz, Tiago A. Souza, Silvia R. Santos, Louise Cerdeira, Valéria Cassettari, Nilton Lincopan

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

The emergence of hypervirulent Klebsiella pneumoniae (hvKP) with multidrug resistance (MDR) profile is a worrisome public health issue. We report the first draft genome sequence of a hypermucoviscous (positive string test) and MDR K. pneumoniae serotype K19, belonging to ST29, isolated from human infection. This strain harboured multiple antimicrobial resistance genes, including blaCTX-M-15, besides yersiniabactin and type 3 fimbriae virulence genes. In vivo experiments carried out with the Galleria mellonella infection model revealed that K. pneumoniae K19/ST29 killed 100% of the larvae at 24 h post-infection, in a similar way to the known hypermucoviscous hvKP K1/ST23 lineage.

Original languageEnglish
JournalPathogens and Disease
Volume75
Issue number9
DOIs
Publication statusPublished - 29 Dec 2017
Externally publishedYes

Keywords

  • Brazil
  • extended-spectrum beta-lactamase
  • Galleria mellonella
  • hvKP
  • K. pneumoniae
  • whole genome sequence

Cite this