Genome-Scale interrogation of the colorectal cancer methylome and transcriptome by microarray

Lochlan J. Fennell

Genome-Scale interrogation of the colorectal cancer methylome and transcriptome by microarray

Lochlan J. Fennell (Photographer)

Research output: Non-textual form › Dataset / Database › Other

Abstract

Colorectal cancer is an epigenetically heterogeneous disease, the extent to which is unclear. In this study we interrogate the methylome of 216 unselected colorectal cancers using Illumina HumanMethylation450 arrays, and correlate these data with transcript profiles and exome sequencing analysis to elucidate the degree of epigenetic dysregulation in colorectal cancers.

Original language	English
Media of output	Online
Publication status	Published - 17 Jul 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-8148Licence: Unspecified

1 Article
1 Dataset / Database

Genome-Scale interrogation of the colorectal cancer methylome by Illumina HumanMethylation450 array
Fennell, L. J., 29 Apr 2019
Research output: Non-textual form › Dataset / Database › Other

Open Access
Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas
Fennell, L., Dumenil, T., Wockner, L., Hartel, G., Nones, K., Bond, C., Borowsky, J., Liu, C., McKeone, D., Bowdler, L., Montgomery, G., Klein, K., Hoffmann, I., Patch, A. M., Kazakoff, S., Pearson, J. V., Waddell, N., Wirapati, P., Lochhead, P., Imamura, Y., & 5 othersOgino, S., Shao, R., Tejpar, S., Leggett, B. & Whitehall, V., Jan 2019, In: Cellular and Molecular Gastroenterology and Hepatology. 8, 2, p. 269-290 22 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

37 Citations (Scopus)

Cite this

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title = "Genome-Scale interrogation of the colorectal cancer methylome and transcriptome by microarray",

abstract = "Colorectal cancer is an epigenetically heterogeneous disease, the extent to which is unclear. In this study we interrogate the methylome of 216 unselected colorectal cancers using Illumina HumanMethylation450 arrays, and correlate these data with transcript profiles and exome sequencing analysis to elucidate the degree of epigenetic dysregulation in colorectal cancers.",

author = "Fennell, {Lochlan J.}",

note = "E-MTAB-8148",

year = "2019",

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language = "English",

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T1 - Genome-Scale interrogation of the colorectal cancer methylome and transcriptome by microarray

A2 - Fennell, Lochlan J.

N1 - E-MTAB-8148

PY - 2019/7/17

Y1 - 2019/7/17

N2 - Colorectal cancer is an epigenetically heterogeneous disease, the extent to which is unclear. In this study we interrogate the methylome of 216 unselected colorectal cancers using Illumina HumanMethylation450 arrays, and correlate these data with transcript profiles and exome sequencing analysis to elucidate the degree of epigenetic dysregulation in colorectal cancers.

AB - Colorectal cancer is an epigenetically heterogeneous disease, the extent to which is unclear. In this study we interrogate the methylome of 216 unselected colorectal cancers using Illumina HumanMethylation450 arrays, and correlate these data with transcript profiles and exome sequencing analysis to elucidate the degree of epigenetic dysregulation in colorectal cancers.

M3 - Dataset / Database

ER -

Genome-Scale interrogation of the colorectal cancer methylome and transcriptome by microarray

Abstract

UN SDGs

Access to Document

Research output

Genome-Scale interrogation of the colorectal cancer methylome by Illumina HumanMethylation450 array

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas

Cite this