Genome-scale DNA methylation analyses of cancer in children

Nicholas C. Wong, David M. Ashley

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Introduction Although rare, cancer is a leading cause of disease mortality in children after accidents, homicides, and suicides (Ries et al., 1999). The biology of cancer in children is markedly different to cancer in adults. This is highlighted by the disparate incidence and etiology of common cancers found between children and adults (AIHW and AACR, 2004). In children, leukemia and brain tumors predominate in newly diagnosed cases, while breast, colorectal, melanoma, and lung cancer are common cancers in adults. While there seems to be a genetic basis for adult cancers, where familial cases of breast (reviewed in Narod and Foulkes, 2004) and colorectal (reviewed in Jasperson et al., 2010) cancer have identified mutations of candidate risk genes, the same can not be said for childhood cancer. The precise causes of childhood cancer still remain unknown. With the scarce number of cases of familial or inherited cancers in children, it would seem that genetics plays a minor role in childhood cancer. Tumours acquire somatic mutation during their progression to cancer and it has long been hypothesized that selected environmental exposures can accelerate mutation rate in tumours that have given rise to their presentation as cancer in children (Knudson, 1976). There is a proposed list of high-risk exposures including radiation, infection, and pesticides associated with childhood cancer (reviewed in Anderson, 2006); however, the small study numbers used to identify these factors have led to small effect sizes and have been difficult to reproduce. Large, multi-center prospective cohort studies have begun to address this issue (Brown et al., 2007).

Original languageEnglish
Title of host publicationEpigenomics: From Chromatin Biology to Therapeutics
PublisherCambridge University Press
Pages338-346
Number of pages9
ISBN (Electronic)9780511777271
ISBN (Print)9781107003828
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Cite this

Wong, N. C., & Ashley, D. M. (2012). Genome-scale DNA methylation analyses of cancer in children. In Epigenomics: From Chromatin Biology to Therapeutics (pp. 338-346). Cambridge University Press. https://doi.org/10.1017/CBO9780511777271.030
Wong, Nicholas C. ; Ashley, David M. / Genome-scale DNA methylation analyses of cancer in children. Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, 2012. pp. 338-346
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Wong, NC & Ashley, DM 2012, Genome-scale DNA methylation analyses of cancer in children. in Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, pp. 338-346. https://doi.org/10.1017/CBO9780511777271.030

Genome-scale DNA methylation analyses of cancer in children. / Wong, Nicholas C.; Ashley, David M.

Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, 2012. p. 338-346.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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Wong NC, Ashley DM. Genome-scale DNA methylation analyses of cancer in children. In Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press. 2012. p. 338-346 https://doi.org/10.1017/CBO9780511777271.030