TY - JOUR
T1 - Genome organization in immune cells
T2 - unique challenges
AU - Johanson, Timothy M.
AU - Chan, Wing Fuk
AU - Keenan, Christine R.
AU - Allan, Rhys S.
N1 - Funding Information:
The authors thank S. Nutt, A. Johanson, N. Alpern and H. Batterham for constructive discussion. This work was supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia (R.S.A.: #1049307 and #1100451; T.M.J.: #1124081; and C.R.K.: #1125436) and the Australian Research Council (R.S.A.: #130100541). This study was made possible through the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme.
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Each type of cell in the immune system performs critical functions to protect the body and maintain health. In order to fulfil these roles some immune cells rely on unique processes, including antigen receptor loci recombination, clonal expansion or the contortion of their nuclei. In turn, each of these processes relies on, or poses unique challenges to, a genome organized in three dimensions. Here, we explore the current understanding of the importance of 3D genome organization in the function and development of a healthy immune system.
AB - Each type of cell in the immune system performs critical functions to protect the body and maintain health. In order to fulfil these roles some immune cells rely on unique processes, including antigen receptor loci recombination, clonal expansion or the contortion of their nuclei. In turn, each of these processes relies on, or poses unique challenges to, a genome organized in three dimensions. Here, we explore the current understanding of the importance of 3D genome organization in the function and development of a healthy immune system.
UR - https://www.scopus.com/pages/publications/85063896879
U2 - 10.1038/s41577-019-0155-2
DO - 10.1038/s41577-019-0155-2
M3 - Review Article
C2 - 30926914
AN - SCOPUS:85063896879
SN - 1474-1733
VL - 19
SP - 448
EP - 456
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 7
ER -