TY - JOUR
T1 - Genistein
T2 - A potential natural lead molecule for new drug design and development for treating memory impairment
AU - Fuloria, Shivkanya
AU - Yusri, Muhamad Azrul Amir
AU - Sekar, Mahendran
AU - Gan, Siew Hua
AU - Rani, Nur Najihah Izzati Mat
AU - Lum, Pei Teng
AU - Ravi, Subban
AU - Subramaniyan, Vetriselvan
AU - Azad, Abul Kalam
AU - Jeyabalan, Srikanth
AU - Wu, Yuan Seng
AU - Meenakshi, Dhanalekshmi Unnikrishnan
AU - Sathasivam, Kathiresan V.
AU - Fuloria, Neeraj Kumar
N1 - Funding Information:
All the authors of this manuscript are thankful to their respective Depart-ments/Universities for successful completion of this study. The figures in this manuscript has been created with the support of https://biorender.com under a paid subscription (Ref: C08A1A0B-0002; accessed on 3 November 2021).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the effects of genistein in the brain, including its pharmacokinetics, bioavailability, behavioral effects, and some of the potential mechanisms of action on memory in several animal models. The results of the preclinical studies highly suggested that genistein is highly effective in enhancing the cognitive performance of the MI animal models, specifically in the memory domain, including spatial, recognition, retention, and reference memories, through its ability to reduce oxidative stress and attenuate neuroinflammation. This review also highlighted challenges and opportunities to improve the drug delivery of genistein for treating MI. Along with that, the possible structural modifications and derivatives of genistein to improve its physicochemical and drug-likeness properties are also discussed. The outcomes of the review proved that genistein can enhance the cognitive performance and ameliorate MI in different preclinical studies, thus indicating its potential as a natural lead for the design and development of a novel neuroprotective drug.
AB - Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the effects of genistein in the brain, including its pharmacokinetics, bioavailability, behavioral effects, and some of the potential mechanisms of action on memory in several animal models. The results of the preclinical studies highly suggested that genistein is highly effective in enhancing the cognitive performance of the MI animal models, specifically in the memory domain, including spatial, recognition, retention, and reference memories, through its ability to reduce oxidative stress and attenuate neuroinflammation. This review also highlighted challenges and opportunities to improve the drug delivery of genistein for treating MI. Along with that, the possible structural modifications and derivatives of genistein to improve its physicochemical and drug-likeness properties are also discussed. The outcomes of the review proved that genistein can enhance the cognitive performance and ameliorate MI in different preclinical studies, thus indicating its potential as a natural lead for the design and development of a novel neuroprotective drug.
KW - Genistein
KW - Isoflavone
KW - Memory impairment
KW - Neuroprotection
KW - Phytomedicine
UR - http://www.scopus.com/inward/record.url?scp=85122063068&partnerID=8YFLogxK
U2 - 10.3390/molecules27010265
DO - 10.3390/molecules27010265
M3 - Review Article
C2 - 35011497
AN - SCOPUS:85122063068
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 1
M1 - 265
ER -