TY - JOUR
T1 - 'Genipin' - the natural water soluble cross-linking agent and its importance in the modified drug delivery systems
T2 - An overview
AU - Manickam, Balamurugan
AU - Sreedharan, Rajesh
AU - Elumalai, Manogaran
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - One of the popular approaches in controlling drug delivery from the polymeric carriers is suitably achieved by the inclusion of crosslinking agents into the formulations at different concentrations. Nevertheless, addition of the chemical crosslinkers such as glutaraldehyde, formaldehyde etc, used in the drug delivery systems causes very serious cytotoxic reactions. These chemical crosslinking agents did not offer any significant advantageous effects when compared to the natural crosslinking agents for instance genipin, which is quite less toxic, biocompatible and offers very stable crosslinked products. Based on the earlier reports the safety of this particular natural crosslinker is very well established, since it has been widely used as a Chinese traditional medicine for long-time, isolated from fruits of the plant Gardenia jasminoides Ellis. This concise article largely portrayed the value of this unique natural crosslinker, utilized in controlling the drug delivery from the various formulations.
AB - One of the popular approaches in controlling drug delivery from the polymeric carriers is suitably achieved by the inclusion of crosslinking agents into the formulations at different concentrations. Nevertheless, addition of the chemical crosslinkers such as glutaraldehyde, formaldehyde etc, used in the drug delivery systems causes very serious cytotoxic reactions. These chemical crosslinking agents did not offer any significant advantageous effects when compared to the natural crosslinking agents for instance genipin, which is quite less toxic, biocompatible and offers very stable crosslinked products. Based on the earlier reports the safety of this particular natural crosslinker is very well established, since it has been widely used as a Chinese traditional medicine for long-time, isolated from fruits of the plant Gardenia jasminoides Ellis. This concise article largely portrayed the value of this unique natural crosslinker, utilized in controlling the drug delivery from the various formulations.
KW - Crosslinking
KW - Drug delivery systems
KW - Genipin
UR - http://www.scopus.com/inward/record.url?scp=84894074680&partnerID=8YFLogxK
U2 - 10.2174/15672018113106660059
DO - 10.2174/15672018113106660059
M3 - Article
C2 - 24041312
AN - SCOPUS:84894074680
VL - 11
SP - 139
EP - 145
JO - Current Drug Delivery
JF - Current Drug Delivery
SN - 1567-2018
IS - 1
ER -