'Genipin' - the natural water soluble cross-linking agent and its importance in the modified drug delivery systems: An overview

Balamurugan Manickam, Rajesh Sreedharan, Manogaran Elumalai

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92 Citations (Scopus)


One of the popular approaches in controlling drug delivery from the polymeric carriers is suitably achieved by the inclusion of crosslinking agents into the formulations at different concentrations. Nevertheless, addition of the chemical crosslinkers such as glutaraldehyde, formaldehyde etc, used in the drug delivery systems causes very serious cytotoxic reactions. These chemical crosslinking agents did not offer any significant advantageous effects when compared to the natural crosslinking agents for instance genipin, which is quite less toxic, biocompatible and offers very stable crosslinked products. Based on the earlier reports the safety of this particular natural crosslinker is very well established, since it has been widely used as a Chinese traditional medicine for long-time, isolated from fruits of the plant Gardenia jasminoides Ellis. This concise article largely portrayed the value of this unique natural crosslinker, utilized in controlling the drug delivery from the various formulations.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalCurrent Drug Delivery
Issue number1
Publication statusPublished - 2014
Externally publishedYes


  • Crosslinking
  • Drug delivery systems
  • Genipin

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