Genetics of nasopharyngeal carcinoma and molecular signaling pathways

Murtala B. Abubakar, Siew Hua Gan

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Nasopharyngeal carcinoma (NPC) is a distinctive type of cancer with considerable geographical and racial distribution. It is a multifactorial disease associated with genetic and environmental factors as well as Epstein-Barr virus infection. Increased understanding of molecular events in NPC development leads to renewed interest in personalized treatment of the disease. Recent studies have demonstrated that NPC is associated with a low mutation rate, considerable epigenetic alterations, and dysregulation of microRNAs and long noncoding RNAs. Discovery of genetic and epigenetic biomarkers promises a better future in improving early detection and prognosis of NPC. This chapter presents the genomic and epigenetic landscapes of NPC and the role of genomic profile in targeted therapy. It discusses the potential application of genetic and epigenetic screening of NPC with an aim to provide early detection of the disease using molecular biomarkers. It is limited documented data on molecular targeted therapy of NPC using genetic and epigenetic markers, thus more studies are needed for full integration of such biomarkers into the management of NPC.

Original languageEnglish
Title of host publicationAn Evidence-Based Approach to the Management of Nasopharyngeal Cancer
Subtitle of host publicationFrom Basic Science to Clinical Presentation and Treatment
EditorsBaharudin Abdullah, Anusha Balasubramanian, Norhafiza Mat Lazim
Place of PublicationLondon UK
PublisherElsevier
Chapter3
Pages31-66
Number of pages36
Edition1st
ISBN (Electronic)9780128144039
ISBN (Print)9780128144046
DOIs
Publication statusPublished - 2020

Keywords

  • EBV
  • epigenetics
  • Epstein-Barr virus
  • genetics
  • microRNAs
  • Nasopharyngeal carcinoma
  • NPC

Cite this