Genetically modified mouse models for premature ovarian failure (POF)

Krishna Jagarlamudi, Pradeep Reddy, Deepak Adhikari, Kui Liu

Research output: Contribution to journalReview ArticleResearchpeer-review

57 Citations (Scopus)

Abstract

Premature ovarian failure (POF) is a complex disorder that affects approximately 1% of women. POF is characterized by the depletion of functional ovarian follicles before the age of 40 years, and clinically, patients may present with primary amenorrhea or secondary amenorrhea. Although some genes have been hypothesized to be candidates responsible for POF, the etiology of most of the cases is idiopathic, with the underlying causes still unidentified because of the heterogeneity of the disease. In this review, we consider some mutant mouse models that exhibit phenotypes which are comparable to human POF, and we suggest that the use of these mouse models may help us to gain a better understanding of the molecular mechanisms underlying POF in humans.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume315
Issue number1-2
DOIs
Publication statusPublished - 5 Feb 2010
Externally publishedYes

Keywords

  • Follicular development
  • Mouse models
  • Ovary
  • Premature ovarian failure (POF)

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