Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters

Rakesh Naidu, Yip Cheng Har, N A M Taib

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    Abstract

    The purpose of the present study was to evaluate the association between TCF7L2 rs12255372(G/T) or rs7903146(C/T) polymorphism and breast cancer risk, and clinico-pathologic characteristics of the patients. Genotyping of these polymorphisms was performed on 387 breast cancer patients and 252 normal and healthy women who had no history of any malignancy using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population.
    Original languageEnglish
    Pages (from-to)411 - 417
    Number of pages7
    JournalMedical Oncology
    Volume29
    Issue number2
    DOIs
    Publication statusPublished - 2012

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