TY - JOUR
T1 - Genetic networks governing heart development
AU - Waardenberg, Ashley J.
AU - Ramialison, Mirana
AU - Bouveret, Romaric
AU - Harvey, Richard P.
PY - 2014/11
Y1 - 2014/11
N2 - Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
AB - Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
UR - http://www.scopus.com/inward/record.url?scp=84923931488&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a013839
DO - 10.1101/cshperspect.a013839
M3 - Article
C2 - 25280899
AN - SCOPUS:84923931488
SN - 2157-1422
JO - Cold Spring Harbor Perspectives in Medicine
JF - Cold Spring Harbor Perspectives in Medicine
M1 - a013839
ER -