Genetic networks governing heart development

Ashley J. Waardenberg, Mirana Ramialison, Romaric Bouveret, Richard P. Harvey

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)


Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.

Original languageEnglish
Article numbera013839
Number of pages23
JournalCold Spring Harbor Perspectives in Medicine
Publication statusPublished - Nov 2014

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