Genetic hypertension accelerates nephropathy in the streptozotocin diabetic rat

M. E. Cooper, T. J. Allen, P. Macmillan, L. Bach, G. Ferums, A. E. Doyle

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To evaluate whether hypertension is a cause or just an association with diabetic renal disease, diabetes was induced in both normotensive Wistar-Kyoto and spontaneously hypertensive rats (WKY and SHR). Animals were assessed monthly for 8 months before sacrifice. When compared to normotensive diabetic rats (WKY-STZ), hypertensive diabetic rats (SHR-STZ) had an earlier and more rapid rise in urinary albumin excretion. In addition, SHR-STZ had increased glomerular basement membrane thickness when compared to WKY-STZ or SHR. In a separate experiment, Enalapril therapy (35 mg/L) was administered in drinking water to WKY-STZ and SHR-STZ. Enalapril significantly reduced blood pressure in both animal groups, and this was associated with a decrease in urinary albumin excretion. The SHR-STZ model has accelerated nephropathy as determined by both functional and structural parameters. Angiotensin-converting enzyme inhibition is associated with a reduction in albuminuria in both hypertensive and normotensive models of diabetic nephropathy.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalAmerican Journal of Hypertension
Issue number1
Publication statusPublished - Jan 1988
Externally publishedYes


  • Albuminuria
  • Diabetes
  • Hypertension
  • Nephropathy

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