TY - JOUR
T1 - Genetic diversity of the African malaria vector Anopheles gambiae
AU - Anopheles gambiae 1000 Genomes Consortium
AU - Miles, Alistair
AU - Harding, Nicholas J.
AU - Bottà, Giordano
AU - Clarkson, Chris S.
AU - Antão, Tiago
AU - Kozak, Krzysztof
AU - Schrider, Daniel R.
AU - Kern, Andrew D.
AU - Redmond, Seth
AU - Sharakhov, Igor
AU - Pearson, Richard D.
AU - Bergey, Christina
AU - Fontaine, Michael C.
AU - Donnelly, Martin J.
AU - Lawniczak, Mara K.N.
AU - Ayala, Diego
AU - Besansky, Nora J.
AU - Burt, Austin
AU - Caputo, Beniamino
AU - Torre, Alessandra Della
AU - Godfray, H. Charles J.
AU - Hahn, Matthew W.
AU - Midega, Janet
AU - Neafsey, Daniel E.
AU - O'Loughlin, Samantha
AU - Pinto, João
AU - Riehle, Michelle M.
AU - Vernick, Kenneth D.
AU - Weetman, David
AU - Wilding, Craig S.
AU - White, Bradley J.
AU - Troco, Arlete D.
AU - Diabaté, Abdoulaye
AU - Costantini, Carlo
AU - Rohatgi, Kyanne R.
AU - Elissa, Nohal
AU - Coulibaly, Boubacar
AU - Dinis, João
AU - Mbogo, Charles
AU - Bejon, Philip
AU - Mawejje, Henry D.
AU - Stalker, Jim
AU - Rockett, Kirk
AU - Drury, Eleanor
AU - Mead, Daniel
AU - Jeffreys, Anna
AU - Hubbart, Christina
AU - Rowlands, Kate
AU - Isaacs, Alison T.
AU - Jyothi, Dushyanth
AU - Malangone, Cinzia
AU - Vauterin, Paul
AU - Jeffery, Ben
AU - Wright, Ian
AU - Hart, Lee
AU - Kluczyński, Krzysztof
AU - Cornelius, Victoria
AU - Macinnis, Bronwyn
AU - Henrichs, Christa
AU - Giacomantonio, Rachel
AU - Kwiatkowski, Dominic P.
PY - 2017/12/7
Y1 - 2017/12/7
N2 - The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
AB - The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
KW - Genetic variation
KW - Malaria
KW - Next
KW - generation sequencing
UR - https://www.scopus.com/pages/publications/85038811995
U2 - 10.1038/nature24995
DO - 10.1038/nature24995
M3 - Article
C2 - 29186111
SN - 0028-0836
VL - 552
SP - 96
EP - 100
JO - Nature
JF - Nature
IS - 7683
ER -
SDG 3 Good Health and Well-being