Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013

Martin Linster, Celeste Donato, Marcus G. Mah, Miguel L. Grau, Jenny G. Low, Eng Eong Ooi, Yvonne C.F. Su, Gavin J.D. Smith, Dhanasekaran Vijaykrishna

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Abstract

To understand the genetic diversity and patterns of circulation of rhinoviruses (RV) and enteroviruses (EV) in Singapore, we retrospectively screened 2950 nasal swab samples collected from adults presenting to primary care services with signs of febrile illness in Singapore during 2007-2013 using sequencing and phylogenetic methods. Through sequencing and phylogenetic analysis, our results show the year-round circulation of the three rhinovirus species, A, B, and C. A diverse set of RV/EV serotypes were detected in Singapore with a predominance of RV-A in all years, whereas serotypes EV-C A21 and EV-D68 were only sporadically detected. This study highlights the previously unrecognized diversity and burden in the adult population in Singapore.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalInfluenza and other Respiratory Viruses
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2020

Keywords

  • enterovirus
  • febrile illness
  • phylogenetic analysis
  • rhinovirus
  • serotypes
  • Singapore
  • virus diversity

Cite this

Linster, M., Donato, C., Mah, M. G., Grau, M. L., Low, J. G., Ooi, E. E., Su, Y. C. F., Smith, G. J. D., & Vijaykrishna, D. (2020). Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore, 2007-2013. Influenza and other Respiratory Viruses, 14(1), 67-71. https://doi.org/10.1111/irv.12662