Genetic detoxification of bacterial toxins: A new approach to vaccine development

Rino Rappuoli, Gill Douce, Gordon Dougan, Mariagrazia Pizza

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of inimunogens with unique properties, some of which may be used for innovative approaches to vaccination.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume108
Issue number4
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Adjuvants
  • Antigen presentation
  • Cholera
  • Escherichia coli enterotoxiti
  • Mucosal immunity
  • Pertussis
  • Toxins
  • Vaccines

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