Genetic detoxification of bacterial toxins: A new approach to vaccine development

Rino Rappuoli; Gill Douce; Gordon Dougan; Mariagrazia Pizza

doi:10.1159/000237176

Genetic detoxification of bacterial toxins: A new approach to vaccine development

Rino Rappuoli, Gill Douce, Gordon Dougan, Mariagrazia Pizza

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of inimunogens with unique properties, some of which may be used for innovative approaches to vaccination.

Original language	English
Pages (from-to)	327-333
Number of pages	7
Journal	International Archives of Allergy and Immunology
Volume	108
Issue number	4
DOIs	https://doi.org/10.1159/000237176
Publication status	Published - 1 Jan 1995
Externally published	Yes

Keywords

Adjuvants
Antigen presentation
Cholera
Escherichia coli enterotoxiti
Mucosal immunity
Pertussis
Toxins
Vaccines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000237176

Cite this

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title = "Genetic detoxification of bacterial toxins: A new approach to vaccine development",

abstract = "Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of inimunogens with unique properties, some of which may be used for innovative approaches to vaccination.",

keywords = "Adjuvants, Antigen presentation, Cholera, Escherichia coli enterotoxiti, Mucosal immunity, Pertussis, Toxins, Vaccines",

author = "Rino Rappuoli and Gill Douce and Gordon Dougan and Mariagrazia Pizza",

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doi = "10.1159/000237176",

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T2 - A new approach to vaccine development

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AU - Douce, Gill

AU - Dougan, Gordon

AU - Pizza, Mariagrazia

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Y1 - 1995/1/1

N2 - Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of inimunogens with unique properties, some of which may be used for innovative approaches to vaccination.

AB - Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of inimunogens with unique properties, some of which may be used for innovative approaches to vaccination.

KW - Adjuvants

KW - Antigen presentation

KW - Cholera

KW - Escherichia coli enterotoxiti

KW - Mucosal immunity

KW - Pertussis

KW - Toxins

KW - Vaccines

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JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 4

ER -

Genetic detoxification of bacterial toxins: A new approach to vaccine development

Abstract

Keywords

UN SDGs

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