Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families

Hemant Kulkarni, Manju Mamtani, Gerard Wong, Jacquelyn M Weir, Christopher K. Barlow, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, Ravindranath Duggirala, Peter J. Meikle, John Blangero, Joanne E Curran

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits. Results: We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits. Conclusions: Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D.

Original languageEnglish
Article number48
Number of pages8
JournalBMC Genetics
Volume18
Issue number1
DOIs
Publication statusPublished - 19 May 2017
Externally publishedYes

Keywords

  • Bivariate trait analyses
  • Family studies
  • Genetic correlation
  • Plasma lipidome
  • Type 2 diabetes

Cite this

Kulkarni, Hemant ; Mamtani, Manju ; Wong, Gerard ; Weir, Jacquelyn M ; Barlow, Christopher K. ; Dyer, Thomas D ; Almasy, Laura ; Mahaney, Michael C ; Comuzzie, Anthony G ; Duggirala, Ravindranath ; Meikle, Peter J. ; Blangero, John ; Curran, Joanne E. / Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families. In: BMC Genetics. 2017 ; Vol. 18, No. 1.
@article{d140ab463be846ba8eabbb28db8f4847,
title = "Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families",
abstract = "Background: Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits. Results: We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits. Conclusions: Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D.",
keywords = "Bivariate trait analyses, Family studies, Genetic correlation, Plasma lipidome, Type 2 diabetes",
author = "Hemant Kulkarni and Manju Mamtani and Gerard Wong and Weir, {Jacquelyn M} and Barlow, {Christopher K.} and Dyer, {Thomas D} and Laura Almasy and Mahaney, {Michael C} and Comuzzie, {Anthony G} and Ravindranath Duggirala and Meikle, {Peter J.} and John Blangero and Curran, {Joanne E}",
year = "2017",
month = "5",
day = "19",
doi = "10.1186/s12863-017-0515-5",
language = "English",
volume = "18",
journal = "BMC Genetics",
issn = "1471-2156",
publisher = "Springer-Verlag London Ltd.",
number = "1",

}

Kulkarni, H, Mamtani, M, Wong, G, Weir, JM, Barlow, CK, Dyer, TD, Almasy, L, Mahaney, MC, Comuzzie, AG, Duggirala, R, Meikle, PJ, Blangero, J & Curran, JE 2017, 'Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families' BMC Genetics, vol. 18, no. 1, 48. https://doi.org/10.1186/s12863-017-0515-5

Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families. / Kulkarni, Hemant; Mamtani, Manju; Wong, Gerard; Weir, Jacquelyn M; Barlow, Christopher K.; Dyer, Thomas D; Almasy, Laura; Mahaney, Michael C; Comuzzie, Anthony G; Duggirala, Ravindranath ; Meikle, Peter J.; Blangero, John; Curran, Joanne E.

In: BMC Genetics, Vol. 18, No. 1, 48, 19.05.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Genetic correlation of the plasma lipidome with type 2 diabetes, prediabetes and insulin resistance in Mexican American families

AU - Kulkarni, Hemant

AU - Mamtani, Manju

AU - Wong, Gerard

AU - Weir, Jacquelyn M

AU - Barlow, Christopher K.

AU - Dyer, Thomas D

AU - Almasy, Laura

AU - Mahaney, Michael C

AU - Comuzzie, Anthony G

AU - Duggirala, Ravindranath

AU - Meikle, Peter J.

AU - Blangero, John

AU - Curran, Joanne E

PY - 2017/5/19

Y1 - 2017/5/19

N2 - Background: Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits. Results: We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits. Conclusions: Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D.

AB - Background: Differential plasma concentrations of circulating lipid species are associated with pathogenesis of type 2 diabetes (T2D). Whether the wide inter-individual variability in the plasma lipidome contributes to the genetic basis of T2D is unknown. Here, we investigated the potential overlap in the genetic basis of the plasma lipidome and T2D-related traits. Results: We used plasma lipidomic data (1202 pedigreed individuals, 319 lipid species representing 23 lipid classes) from San Antonio Family Heart Study in Mexican Americans. Bivariate trait analyses were used to estimate the genetic and environmental correlation of all lipid species with three T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insulin resistance. We found that 44 lipid species were significantly genetically correlated with one or more of the three T2D-related traits. Majority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TAG, 17 species) classes. Six lipid species (all belonging to the triacylglycerol class and containing palmitate at the first position) were significantly genetically correlated with all the T2D-related traits. Conclusions: Our results imply that: a) not all plasma lipid species are genetically informative for T2D pathogenesis; b) the DAG and TAG lipid classes partially share genetic basis of T2D; and c) 1-palmitate containing TAGs may provide additional insights into the genetic basis of T2D.

KW - Bivariate trait analyses

KW - Family studies

KW - Genetic correlation

KW - Plasma lipidome

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85019373673&partnerID=8YFLogxK

U2 - 10.1186/s12863-017-0515-5

DO - 10.1186/s12863-017-0515-5

M3 - Article

VL - 18

JO - BMC Genetics

JF - BMC Genetics

SN - 1471-2156

IS - 1

M1 - 48

ER -