Genetic control of T helper cell function in the clawed toad Xenopus laevis

Claude C.A. Bernard, Gérard Bordmann, Bonnie Blomberg, Louis Du Pasquier

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The genetic control of the collaboration between Xenopus T and B cells has been analyzed in vitro using cells from five strains of major histocompatibility complex‐defined Xenopus. When carrier (fowl gamma‐globulin)‐primed T cells and hapten (dinitrophenylated keyhole limpet hemocyanin)‐primed B cells differed by minor histocompatiblity antigens or by only one haplotype of the major histocompatibility complex, the collaboration was efficient in the sense that large numbers of plaques, low‐molecular weight antibodies and high‐affinity IgM antibodies could be recorded in the cultures challenged with dinitrophenylated fowl gamma‐globulin. However, when T and B cells differed at both alleles of the major histocompatibility complex, lower numbers of plaques were obtained, no low‐molecular weight anti‐hapten antibodies could be detected, and the IgM antibodies that were sometimes synthesized were of low affinity. This suggests that the major histocompatibility complex, or a gene linked with it, affects the collaboration between Xenopus T and B cells in a way perhaps similar to that described in mammals.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalEuropean Journal of Immunology
Issue number2
Publication statusPublished - 1981
Externally publishedYes

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