Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse

Catherine M. Browne; Gary R. Hime; Peter Koopman; Kate L. Loveland

doi:10.1007/s00441-005-1128-2

Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse

Catherine M. Browne, Gary R. Hime, Peter Koopman, Kate L. Loveland

Research output: Contribution to journal › Review Article › Research › peer-review

2 Citations (Scopus)

Abstract

The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.

Original language	English
Pages (from-to)	5-19
Number of pages	15
Journal	Cell and Tissue Research
Volume	322
Issue number	1
DOIs	https://doi.org/10.1007/s00441-005-1128-2
Publication status	Published - 1 Oct 2005
Externally published	Yes

Keywords

Carcinoma in situ
Choriocarcinoma
Drosophila models
Embryonal carcinoma
Embryonal stem cells
Human
Mouse models
Seminoma
Teratoma
Yolk sac tumour

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00441-005-1128-2

Cite this

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title = "Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse",

abstract = "The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.",

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T2 - Insights from the fruitfly and mouse

AU - Browne, Catherine M.

AU - Hime, Gary R.

AU - Koopman, Peter

AU - Loveland, Kate L.

PY - 2005/10/1

Y1 - 2005/10/1

N2 - The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.

AB - The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.

KW - Carcinoma in situ

KW - Choriocarcinoma

KW - Drosophila models

KW - Embryonal carcinoma

KW - Embryonal stem cells

KW - Human

KW - Mouse models

KW - Seminoma

KW - Teratoma

KW - Yolk sac tumour

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DO - 10.1007/s00441-005-1128-2

M3 - Review Article

C2 - 16094543

AN - SCOPUS:27944462300

SN - 0302-766X

VL - 322

SP - 5

EP - 19

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 1

ER -

Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse

Abstract

Keywords

UN SDGs

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Other files and links

ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology

Cite this

Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

ARC Centre of Excellence - Centre for Free Radical Chemistry and Biotechnology

Cite this