Genetic basis of human testicular germ cell cancer: Insights from the fruitfly and mouse

Catherine M. Browne, Gary R. Hime, Peter Koopman, Kate L. Loveland

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The prevalence of tumours of the germ line is increasing in the male population. This complex disease has a complex aetiology. We examine the contribution of genetic mutations to the development of germ line tumours in this review. In particular, we concentrate on fly and mouse experimental systems in order to demonstrate that mutations in some conserved genes cause pathologies typical of certain human germ cell tumours, whereas other mutations elicit phenotypes that are unique to the experimental model. Despite these experimental systems being imperfect, we show that they are useful models of human testicular germ cell tumourigenesis.

Original languageEnglish
Pages (from-to)5-19
Number of pages15
JournalCell and Tissue Research
Volume322
Issue number1
DOIs
Publication statusPublished - 1 Oct 2005
Externally publishedYes

Keywords

  • Carcinoma in situ
  • Choriocarcinoma
  • Drosophila models
  • Embryonal carcinoma
  • Embryonal stem cells
  • Human
  • Mouse models
  • Seminoma
  • Teratoma
  • Yolk sac tumour

Cite this