Genetic and environmental risk factors for chronic kidney disease

Gregorio T. Obrador, Ulla T. Schultheiss, Matthias Kretzler, Robyn G. Langham, Masaomi Nangaku, Roberto Pecoits-Filho, Carol Pollock, Jerome Rossert, Ricardo Correa-Rotter, Peter Stenvinkel, Robert Walker, Chih Wei Yang, Caroline S. Fox, Anna Köttgen

Research output: Contribution to journalReview ArticleResearchpeer-review

57 Citations (Scopus)

Abstract

In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential. This article first provides an overview of the existing knowledge gaps in our understanding of the genetic and environmental causes of chronic kidney disease, as well as their interactions. The second part of the article formulates goals that should be achieved in order to close these gaps, along with suggested timelines and stakeholders that are to be involved. A better understanding of genetic and environmental factors and their interactions that influence kidney function in healthy and diseased conditions can provide novel insights into renal physiology and pathophysiology and result in the identification of novel therapeutic or preventive targets to tackle the global public health care problem of chronic kidney disease.

Original languageEnglish
Pages (from-to)88-106
Number of pages19
JournalKidney International Supplements
Volume7
Issue number2
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • chronic kidney disease
  • environment
  • genetic kidney disease
  • genetics
  • genome-wide association studies

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